Skip to Main Content
Skip Nav Destination

Recent discovery of potent anti TB activity in sertraline, a popular antidepressant drug which acts via selective serotonin reuptake inhibition, enthused us to search for possible presence of related proteins in Mycobacterium tuberculosis. We used bioinformatic tools and we used Serotonin Reuptake Receptor of 5-HT protein sequence as query and search the Mycobacterium tuberculosis database using protein blast tool. The mycobacterial protein SGC57945.1, a sodium dependant transporter, is selected based on score (identical percentage-25%; similarity-45%) and pursued for homology modelling and binding site prediction. It is interesting to note that, the binding site amino acids of the query were matching with the alignment region. The modeled protein is used for docking simulation to verify binding interactions and also to find possible hits in the DrugBank database. The drugs with highest score were selected and screened against MtbH37rv.

This content is only available via PDF.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal