Toxicity and Breast Cancer Risk Prediction Studies for Carbamates: Bioinformatics Approach Check Access

Pesticides like carbamates are a group of insecticides, widely used in the agricultural sector. Owing to their excessive use in agricultural, domestic, and industrial arenas most of the carbamates are being released into the environment involuntarily. Unintentional or occupational exposure of humans and non-target species to these pesticides may trigger the undesired hazardous consequences. Breast cancer may be one of such consequences and is one of the major life-threatening diseases across the world. However, the ability of these carbamates to induce breast cancer was not well studied and remained elusive. This study was designed to predict the possibility for occurrence of breast cancer upon exposure to the carbamates by interacting with BRCA1 gene using in silico tools. Results of the present investigation revealed that carbamates (propoxur, triallate, carbaryl, allethrin, mobam, butacarb, fenoxycarb and diallate) studied can interact with BRCA1 gene and interfere with the key pathways that are connected with the breast cancer. Furthermore, the findings indicated that the far-reaching impact of their toxicity on human health than their already known effects. These effects need to be validated by in vitro and in vivo methods. This study provides a preliminary yet invaluable information on the carbamates and their possible carcinogenic effect.