Skip to Main Content
Skip Nav Destination

Curcumin is known to possess diverse biological activities. But still it has not been introduced as an effective therapeutic agent due to its poor oral bioavailability and stability in gastrointestinal tract. Curcumin-metformin conjugate synthesized by molecular hybridization approach may overcome these limitations. The objective of the study was to develop liquid chromatography-tandem mass spectrometric (LC-MS/MS) method to quantify curcumin in rat plasma and explore the pharmacokinetic profile of novel curcumin-metformin conjugate in comparison with that of free curcumin. Free curcumin and curcumin-metformin conjugate suspensions were administered by oral route to two groups of Sprague-Dawley rats (n=3) at a dose of 130 mg/rat and 40 mg/rat respectively. Blood samples were collected from retro-orbital plexus at regular time intervals and the plasma was analysed for curcumin by LC-MS/MS. Various pharmacokinetic parameters like peak plasma concentration, time taken to reach maximum concentration, area under the curve and half-life were determined. It was observed that curcumin-metformin conjugate increased the bioavailability of curcumin by 6 times of free curcumin on comparing the AUC0-ꝏ values. The results indicated that conjugation of curcumin with metformin enhanced the bioavailability of curcumin. This strategy of conjugation of curcumin with drugs can be used to increase the bioavailability of curcumin thereby potentiating its numerous pharmacological activities.

This content is only available via PDF.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal