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Eberconazole (EBZ) is a BCS class II drug that has poor solubility and high permeability. Aim of the present research work is to prepare and evaluate Eberconazole Proniosomes. Proniosomes were prepared by thin-film hydration method ratios of nonionic surfactant with cholesterol and keeping drug and DCP constant. Multilamellar Proniosome were prepared by the thin-film hydration method. Accurately weighed quantities of drug, surfactant (Span), and CHOL were dissolved in chloroform in a round-bottom flask. DCP were added to each formulation as a negative charge-inducing agent. The chloroform was evaporated at 60oC under reduced pressure using a rotary flash evaporator at various RPM. After chloroform evaporation, the flask was kept under vacuum overnight in a nitrogen atmosphere to remove residual solvent. The thin films were hydrated with 6 ml of phosphate buffered saline (PBS), pH 5.5 and the formulations were Sonicated 3 times at 50 Hz in a bath- sonicator for 15 min with 5 min interval between successive times. Vesicle suspensions were also Sonicated for 5 min. The Proniosomes were prepared by simple hydration and further evaluated for entrapment efficiency, particle size and shape analysis by optical microscopy, in-vitro drug release study, kinetic data analysis and model fitting. The formulation F6, which showed entrapment efficiency of 97.78% and in-vitro release over the period of 12h 97.35%, was found to be best formulation. The proniosomes follows Peppas release kinetics mechanism.

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