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The current research work deals with the combination of surfactants for vesicular drug delivery of potent chemotherapeutic drugs like capecitabine with advantages of controlled release as well as brain specific targeting. Niosomes formulation was optimized by employing a surface response method in which central composite designed was selected for getting a less number of formulations with better results using Design Expert software version V 11. The niosomes were formulated by using combination of span-80 and brij-78 as non-ionic surfactant by thin film hydration technique in which cholesterol and diacetyl phosphate in constant ratio as per design. Optimized formulation was evaluated for the following parameters like microscopic examination, vesicular size, zeta potential, drug entrapment efficiency, drug content, In-vitro drug release, kinetic studies, and stability studies. Results revealed that the combination of surfactant concentration on the response parameters from statistical optimization method employing various 3D plots and some contour plots for achieving significant results for exhibited a higher retention of Capecitabine inside the vesicles. In-vitro drug release rate was slower at period of 12 hours about 57.01% for optimized formulation. Kinetic evaluation of optimized F10 formulation reported first order drug release with R2 value of 0.9803. The Korsmeyer Peppas model was represented by the release exponent (n) value of 0.0564 indicates that the optimized Niosomal formulation follows a non-Fickian type of drug transport or anomalous diffusion process.

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