Skip to Main Content
Skip Nav Destination

Nebivolol comes under BCS Class II Classification, so there is a need to improve the dissolution rate. The motive of the current work is to formulate the fast-dissolving tablets of Nebivolol from optimised solid dispersion by allowing complexation using solid dispersions of PEG 4000, Starch 1500, Poloxamer 188, and β-cyclodextrin (β CD). Nebivolol tablets with fast dissolution characteristics employing βCD were prepared using a 32 factorial study employing by direct compression technique. Dissolution of Nebivolol from the β-CD complexes was rapid and higher when seen with that of Pure Nebivolol and with different carriers like Poloxamer, PEG 4000, and Starch 1500. Hence β-CD (1:3 M) ratio was selected for the preparation of tablets by 32 factorial study. Nebivolol equivalent to 5mg tablets was prepared by immersing βCD (1:3 M) using Primojel and Crospovidone as super disintegrants through direct compression technique. Tablet powder blends in each case possess excellent flow characteristics suitable for direct compression. All prepared tablets satisfied the I.P disintegration time range of noncoated tablets. The factorial study was used in the formulation of nebivolol tablets in which all three levels of factor X1 (Primojel) and factor X2 (Crospovidone) are of concentration 3%, 4%, 5% (% calculated based on total tablet weight, i.e. 250 mg) were chosen as the hypothesis for the execution of the rapid dissolution of Nebivolol formulations. From the overview, it is evident that an enhancement in the portion of Superdisintegrant tends to decline in the disintegration time of the tablet and increase in drug dissolution.

This content is only available via PDF.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal