Ophthalmic Quercetin Films Preparation and Evaluation Using Euphorbia Hirta

Cataracts cause the lens to become cloudy, which blurs the image. The arrangement of the protein and water in the lens keeps it clear and allows light to pass through. Age-related protein clumping may cause a cataract, which lowers the amount of light reaching the retina, by blocking a small part of the lens. Cataract can be cured without surgery using quercetin films. Quercetin occular films were produced by using a solvent evaporation method using glycerine as a lubricant and were assessed for physical and chemical characteristics, in-vitro drug release experiments, and in vivo release studies. Each polymer’s formulations were assessed for number of factors, including thickness, surface pH, moisture absorption rate, moisture loss rate, and quercetin drug release, in vitro dissolution studies. All the formulations were tested with formulation release rate by using dissolution process, therapeutic action was tested by using preclinical studies on Wister albino rats for the parameters like decrease in opacity index, when compared to the naphthalene control and standard drug isotine drops were used for measuring the therapeutic parameters. Among all six formulations, F4 formulation drug release rate is high, with 78.9%, at 200 mg concentration. Rats pre-treated with naphthalene for 28 days shows profound decrease in opacity index. Hence may be ophthalmic quercetin films are promising options for the treatment of cataract in upcoming days.