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Neurodegenerative disorders are most prevalent in older patients. The plant, Sida Cordifolia is a perennial shrub which belongs to the family Malvaceae. S. Cordifolia was proved to possess analgesic, hypoglycaemic, hepatoprotective, and antioxidant activities. The main objective of the present work was to screen the neuroprotective potential of the whole plant S. Cordifolia. The preliminary phytochemical and the acute toxicity evaluation of the extract were done. The neuroprotective potential of the extract was evaluated with the help of Y- maze, water maze and step-down inhibitory avoidance test. The biochemical parameters of the isolated brain serum samples of the treated groups were measured. The animals treated with S. Cordifolia has improved short term and long-term memories, escape latencies, exploratory behaviour, and percentage alterations. The group treated with S. Cordifolia plant was proved to have neuroprotective activity by showing improvement in different parameters in above stated models and enhanced levels of different neurotransmitters. Further studies are required to establish the clinical significance of this plant as a neuroprotective agent.

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