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Diabetes mellitus is the commonest form of endocrine disorder that is characteristic of hyperglycaemia. This is due to a defective metabolic system of fat, proteins, and carbohydrates leading to major health challenges. Around 800 medicinal plants have hypoglycaemic properties worldwide. Diabetic complications can be slowed and metabolic abnormalities can be restored by the use of plant products. The antidiabetic property of Celastrus paniculatus seed extract (CPSE) is studied. The seeds containing phytochemicals - alkaloids, sterols, triterpenoids, flavonoids, saponins, and tannins were evaluated using standard procedures. Single day hypoglycaemic study was done by taking 800 and 1600 mg kg-1 body-weight and blood samples were collected at 0, 30, 60, 120 min. to evaluate blood glucose levels using glucometer. Oral glucose tolerance study was conducted on normal rats by giving 50% glucose solution of 2 g kg-1 body-weight by p.o. route, half an hour after sample and standard drug administration, blood samples were collected 30 min after glucose was given and continued at 60 min, 90 min, and 120 min. Alloxan-induced diabetic study was done by taking 400 mg kg-1 and 800 mg kg-1 doses of CPSE and recording blood glucose levels on 0, 4, 7 14 and 21 days of study. In the histopathological studies of pancreas, the disease control group showed a high degree of hypertrophy and hyperplasia of pancreatic cells. Samples from CPSE 800 mg kg-1 treated group showed no apoptosis or necrosis and normal acinar cells. The results suggest that CPSE may possess antidiabetic action.

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