A Systematic Approach of Research Screening Models of Neurodegenerative Disease Using Zebrafish

Millions of individuals worldwide are affected by neurodegenerative disorders. The most prevalent neurodegenerative disorders are Alzheimer's and Parkinson's. These are the rapidly spreading health concerns in the aged society that lacks effective therapy. Complicated aetiology and clinical diversity of neurodegenerative diseases are making significant progress recently and helping in the development of disease-altering treatments. Among various animal models, zebrafish model has become a substantial in vivo tool to study these neuronal diseases. In the present study, the disease was induced to zebrafish model by giving AlCl3 administration. Changes in the levels of Aβ-42, P-tau inhibitors, scopolamine, okadaic acid, APPIAβ, PSEN1, PSEN2 and cyclic –dependent kinase 5 (CDK5) were observed along with AChE enzyme levels in the zebrafish. In this study, we observed that the induced Alzheimer's disease (AD) has inhibited the Aβ formation via interference by gamma secretase inhibitors (GSIs). Further it was observed that GSIs, not only inhibited the Aβ production but also had an effect on notching signaling. Therefore, AD related drugs are designed in such a way that, they should not trigger the other pathways that may lead to disease progression.