Residual Dipolar Couplings: Principles and Applications
Residual dipolar couplings (RDCs) are NMR measurements widely used to determine structural and dynamic information in small molecules and large macromolecules. This book provides a broad view of RDCs, from basic principles to advanced applications in organic molecules and biomolecules. Exploring the newest developments in RDC measurement and analysis through authoritative accounts written by leaders in the field, this book provides a comprehensive overview on the fundamentals, analysis and applications in one place for the first time.
The versatility and accuracy of RDCs have found a large range of applications in NMR, and their measurement and analysis are major research areas. Readers, be they experts or students, will receive a strong understanding of the fundamentals of RDCs and their applications to their research projects.
Residual Dipolar Couplings: Principles and Applications, Royal Society of Chemistry, 2024.
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Table of contents
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Chapter 1: Introduction to Residual Dipolar Couplingp1-4ByLishan Yao;Lishan YaoaQingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaSearch for other works by this author on:Beat Vögeli;Beat VögelibDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora 80045, CO, USASearch for other works by this author on:Ad BaxAd BaxcLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USASearch for other works by this author on:
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Chapter 2: Theoretical Aspects of Residual Dipolar Couplingsp5-22ByKe Ruan;Ke RuanaThe First Affiliated Hospital & School of Life Sciences, Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Biomedical Sciences and Health Laboratory of Anhui Province, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, ChinaSearch for other works by this author on:Joel R. TolmanJoel R. TolmanbDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USASearch for other works by this author on:
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Chapter 3: External Media for Inducing Weak Alignment in Biomacromoleculesp23-54BySebastian Meier;Sebastian MeieraDepartment of Chemistry Technical University of Denmark Kemitorvet, 2800 Kgs. Lyngby (Denmark)Search for other works by this author on:Stephan GrzesiekStephan GrzesiekbBiozentrum der Universität Basel Klingelbergstr. 50-70, 4056 Basel (Switzerland)Search for other works by this author on:
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Chapter 4: Generating Independent RDCs Using Paramagnetic Tagsp55-75ByJia-Liang Chen;Jia-Liang ChenState Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, ChinaSearch for other works by this author on:Xun-Cheng SuXun-Cheng SuState Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, ChinaSearch for other works by this author on:
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Chapter 5: Prediction of Weak Alignment from Molecule Structurep76-106ByM. ZweckstetterM. ZweckstetteraResearch Group Translational Structural Biology, German Center for Neurodegenerative Diseases (DZNE), Göttingen, GermanybDepartment for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, Göttingen, GermanySearch for other works by this author on:
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Chapter 6: NMR Experiments for Measuring RDCs in Biomoleculesp107-130ByN. C. Fitzkee;N. C. FitzkeeaDepartment of Chemistry, Mississippi State University, Mississippi State, MS 39762, USASearch for other works by this author on:R. Yadav;R. YadavbDepartment of Physical Sciences, University of Arkansas – Fort Smith, Fort Smith, AR 72913, USASearch for other works by this author on:J. YingJ. YingcLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USASearch for other works by this author on:
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Chapter 7: Study of Biomolecular Structure and Dynamics with Xplor-NIHp131-158ByGuillermo A. Bermejo;Guillermo A. BermejoLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USASearch for other works by this author on:Charles D. SchwietersCharles D. SchwietersLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USASearch for other works by this author on:
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Chapter 8: RDC for Membrane Proteinsp159-180ByJames J. ChouJames J. ChouDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USASearch for other works by this author on:
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Chapter 9: Consistent Protein Structure Determination Using Sparse NMR Datap181-205ByYang ShenYang ShenLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USASearch for other works by this author on:
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Chapter 10: RNA Conformational Ensembles from NMR Residual Dipolar Couplingsp206-251ByRohit Roy;Rohit RoyaCenter for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC 27710, USASearch for other works by this author on:Ainan Geng;Ainan GengbDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USASearch for other works by this author on:Supriya Pratihar;Supriya PratiharcDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USASearch for other works by this author on:Honglue Shi;Honglue ShidDepartment of Chemistry, Duke University, Durham, NC 27708, USASearch for other works by this author on:Hashim M. Al-HashimiHashim M. Al-HashimicDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USASearch for other works by this author on:
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Chapter 11: Structure Determination of Organic Molecules Using RDCs (and RCSAs)p252-279ByJ. Rettig;J. RettigTechnische Universität Darmstadt, Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Peter-Grünberg-Straße 16, 64287 Darmstadt, GermanySearch for other works by this author on:M. Brauser;M. BrauserTechnische Universität Darmstadt, Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Peter-Grünberg-Straße 16, 64287 Darmstadt, GermanySearch for other works by this author on:C. M. ThieleC. M. ThieleTechnische Universität Darmstadt, Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Peter-Grünberg-Straße 16, 64287 Darmstadt, GermanySearch for other works by this author on:
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Chapter 12: Using RDCs and PCSs to Study the Structure, Dynamics, and Interactions of Carbohydratesp280-305ByAngeles Canales;Angeles CanalesaDepartment of Organic Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avd. Complutense s/n, 28040, Madrid, SpainSearch for other works by this author on:Paola Oquist-Phillips;Paola Oquist-PhillipsaDepartment of Organic Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avd. Complutense s/n, 28040, Madrid, SpainSearch for other works by this author on:Ana Poveda;Ana PovedabCIC bioGUNE, Bizkaia Science and Technology Park, 48160, Bilbao, SpainSearch for other works by this author on:Jesús Jiménez-BarberoJesús Jiménez-BarberobCIC bioGUNE, Bizkaia Science and Technology Park, 48160, Bilbao, SpaincIKERBASQUE, Basque Foundation for Science, 48009, Bilbao, SpaindDepartment of Organic Chemistry, II Faculty of Science and Technology University of the Basque Country, EHU-UPV, 48940 Leioa, SpaineCentro de Investigación Biomédica En Red de Enfermedades Respiratorias, Madrid, SpainSearch for other works by this author on:
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Chapter 13: Anisotropic NMR Methods: Orthogonal Verification of Novel and Complex Natural Product Structuresp306-369ByGary E. Martin;Gary E. MartinbSeton Hall, South Orange, NJ, USASearch for other works by this author on:Gao-Wei Li;Gao-Wei LicShangqiu Normal University, Shangqiu, Henan, ChinaSearch for other works by this author on:Xinxiang Lei;Xinxiang LeidLanzhou University, Lanzhou, Gansu, ChinaSearch for other works by this author on:R. Thomas WilliamsonR. Thomas WilliamsoneUNC Wilmington, Wilmington, NC, USASearch for other works by this author on:
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