Magnetic Resonance and its Applications in Drug Formulation and Delivery
This book details the latest research and development in the use of magnetic resonance imaging and spectroscopy as tools to give quantitative insights concerning late stage pharmaceutical formulation, tablet manufacturing and drug dissolution behaviour. The book combines different facets of magnetic resonance and highlights the use of spatial resolution (MRI) and how this adds to the knowledge base to further our understanding of the microscopic physicochemical processes occurring during drug release from solid dosage forms. New topics, that have not been thoroughly reviewed elsewhere, are covered including the applications of solution state magnetic resonance in process scale up, reaction monitoring/understanding and process analytical technologies (PAT); dissolution testing; and counterfeit analysis. Solid state NMR and its role in understanding phase separation in dispersions, polymorphism and crystallography is included and magnetic resonance imaging and its use in assessing tablet dissolution performance, mass transport and mixing in hot melt extrusion (HME) are covered.Focusing on late stage development rather than molecular drug discovery provides a unique approach and the book will appeal to a diversity of disciplines using spectroscopy for study. Aimed at researchers in drug development, manufacture and formulation in both industry (pharmaceutical companies) and academia (pharmacy program), it includes examples, where appropriate, of studies on commercially available pharmaceutical products.
Magnetic Resonance and its Applications in Drug Formulation and Delivery, Royal Society of Chemistry, 2024.
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Table of contents
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Chapter 1: Applications of NMR in Drug Substance and Drug Product Developmentp1-61ByMaria Victoria Silva ElipeMaria Victoria Silva ElipeAttribute Science, Amgen, Inc., One Amgen Center Drive (Mail Stop 30E-1-C), Thousand Oaks, CA 91320, USASearch for other works by this author on:
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Chapter 2: The Application of Magnetic Resonance to Testing Counterfeit, Falsified, and Substandard Medicinesp62-148ByA. McCudden;A. McCuddenNew Modalities & Parenteral Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UKSearch for other works by this author on:K. EmbreyK. EmbreyNew Modalities & Parenteral Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UKSearch for other works by this author on:
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Chapter 3: Nuclear Quadrupole Resonance Spectroscopy in Pharmaceuticalsp149-178ByStephen A. C. Wren;Stephen A. C. WrenPharmaceutical Development, AstraZeneca, Macclesfield, SK10 2NA, UKSearch for other works by this author on:Patrick M. J. SzellPatrick M. J. SzellDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UKSearch for other works by this author on:
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Chapter 4: NMR Crystallography in Pharmaceutical Developmentp179-212ByLeslie P. Hughes;Leslie P. HughesOral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UKSearch for other works by this author on:Patrick M. J. Szell;Patrick M. J. SzellDepartment of Physics, University of Warwick, UKSearch for other works by this author on:Helen Blade;Helen BladeOral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UKSearch for other works by this author on:Steven P. BrownSteven P. BrownDepartment of Physics, University of Warwick, UKSearch for other works by this author on:
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Chapter 5: Using Water Proton NMR to Characterize Aluminum-adjuvanted Vaccinesp213-243ByK. T. Briggs;K. T. BriggsBio- and Nano-Technology Center, University of Maryland School of Pharmacy, and Institute for Bioscience and Biotechnology Research, 9600 Gudelsky Drive, Rockville, Maryland 20850, USASearch for other works by this author on:M. B. Taraban;M. B. TarabanBio- and Nano-Technology Center, University of Maryland School of Pharmacy, and Institute for Bioscience and Biotechnology Research, 9600 Gudelsky Drive, Rockville, Maryland 20850, USASearch for other works by this author on:Y. B. YUY. B. YUBio- and Nano-Technology Center, University of Maryland School of Pharmacy, and Institute for Bioscience and Biotechnology Research, 9600 Gudelsky Drive, Rockville, Maryland 20850, USASearch for other works by this author on:
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Chapter 6: Magnetic Resonance Methods Applied to the Study and Development of Cell Cultures and Bioreactors for Biopharmaceutical Productionp244-277ByMark I. Grimes;Mark I. GrimesDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UKSearch for other works by this author on:Michael D. MantleMichael D. MantleDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UKSearch for other works by this author on:
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Chapter 7: Applications of Pulsed Field Gradient Nuclear Magnetic Resonance to Late-stage Pharmaceutical and Biopharmaceutical Development and Deploymentp278-332ByMichael D. MantleMichael D. MantleDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, England, UKSearch for other works by this author on:
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Chapter 8: Applications of MRI to Study Controlled Drug Release Formulations: From Model Formulations Toward the Understanding of Drug Products Behaviorp333-360ByP. Kulinowski;P. KulinowskiInstitute of Technology, University of the National Education Commission, Kraków, ul. Podchorążych 2, 30-084 Kraków, PolandSearch for other works by this author on:P. DoroŻyŃskiP. DoroŻyŃskiChair of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandSearch for other works by this author on:
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Chapter 9: Short-T2 Imaging Applications in Pharmaceutical Researchp361-379ByB. NewlingB. NewlingDepartment of Physics, University of New Brunswick, PO Box 4400, Fredericton, New Brunswick, E3B 5A3, CanadaSearch for other works by this author on:
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