Neurotransmitters and Toxicology
Neurotransmitters are usually considered to be endogenous substances that are released from neurons, act on receptor sites that are typically present on membranes of postsynaptic cells and produce a functional change in the properties of the target cell. They are essential features of the nervous systems of all animals, and numerous chemicals can act as neurotransmitters either intentionally (e.g. pesticides) or unintentionally (neurotoxins). The most common forms of neurotoxicity are the death of neurons, degeneration of axons, damage to glial cells and interference with the axonal membrane or neurotransmission. Important neurotoxins are found among pesticides, metals, solvents, natural substances, and industrial chemicals. Environmental chemicals may also contribute to the pathology of neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. Neurotransmitters and Toxicology will be particularly appealing to toxicologists interested in neurotoxicology in various sub-disciplines, as well as neuro-chemists interested in pathology and disease mechanisms associated with neurotoxicants.
Neurotransmitters and Toxicology, Royal Society of Chemistry, 2024.
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Table of contents
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Chapter 1: Introductionp1-17ByT. C. MarrsT. C. MarrsSearch for other works by this author on:
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Chapter 2: Cholinergic Neurotransmissionp18-48ByT. C. MarrsT. C. MarrsSearch for other works by this author on:
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Chapter 3: Cholinergic Neurotransmission and Toxicity – Neonicotinoids and Spinosadp49-90
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Chapter 4: Glutamatergic Neurotransmission and Toxicity: Domoic Acid and Kainic Acid (Glutamic Acid Analogs)p91-128ByP. B. BernardP. B. BernardDepartment of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward IslandCharlottetown, PE, C1A 9E7Canada[email protected]Search for other works by this author on:
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Chapter 5: GABAergic Neurotransmission and Toxicity 1: Organochlorinesp129-178ByAndrew G. SmithAndrew G. SmithaMRC Toxicology Unit, University of CambridgeTennis Ct Rd, Cambridge, CB2 1QRUKSearch for other works by this author on:
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Chapter 6: GABAergic Neurotransmission and Toxicity 2: Macrocyclic Lactonesp179-226ByKevin N. WoodwardKevin N. WoodwardSearch for other works by this author on:
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Chapter 7: GABAergic Neurotransmission and Toxicity 3: Isoxazolinesp227-254ByKevin N. WoodwardKevin N. WoodwardSearch for other works by this author on:
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Chapter 8: Monoamine Neurotransmission and Toxicityp255-289ByJ. Del PinoJ. Del PinoDepartment of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid28040 MadridSpain[email protected][email protected]Search for other works by this author on:
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Chapter 9: Cannabinoid Neurotransmission: Neurotoxicity or Neuroprotectionp290-325ByUjendra KumarUjendra KumarFaculty of Pharmaceutical Sciences, The University of British ColumbiaVancouver, British ColumbiaCanada[email protected]Search for other works by this author on:
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