Physical Principles of Chirality in NMR
How can we study one of the most elusive molecular properties, chirality, using nuclear interactions with the magnetic field that are apparently insensitive to handedness? This book answers this question from the physicochemical point of view by providing a clear, coherent, and comprehensive review of methods used in NMR studies of chirality.
Presented arguments based on fundamental physical and chemical laws and in-depth descriptions of new methods utilizing purely physical interactions are mainly addressed to spectroscopists in both academia and industry. The introductory chapters provide the reader with the basics of NMR spectroscopy as a tool for the study of chiral compounds, and those more interested in the methods of chiral discrimination will benefit from the brief description of their common points and reasons why some of them may or may not work. In the following chapters, the book shows rapid progress in a newly emerging field of chirality-sensitive NMR, in particular, a search for effects that give direct information about the absolute configuration of a molecule.
Physical Principles of Chirality in NMR, Royal Society of Chemistry, 2024.
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Table of contents
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Chapter 1: Introduction to Molecular Chiralityp1-32ByP. GarbaczP. GarbaczFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland [email protected]Search for other works by this author on:
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Chapter 2: Fundamentals of Chiral Spectroscopy†p33-58ByPiotr Garbacz;Piotr GarbaczaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland [email protected]Search for other works by this author on:Laurence D. Barron;Laurence D. BarronbDepartment of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK [email protected]Search for other works by this author on:Peer FischerPeer FischercMax Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, GermanydInstitute for Molecular Systems Engineering and Advanced Materials, Heidelberg University, INF 255, 69120 Heidelberg, Germany [email protected]Search for other works by this author on:
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Chapter 3: The Concept of Chirality from a Mathematical Perspectivep59-73ByErica FlapanErica FlapanPomona College, Claremont, CA 91711, USA [email protected]Search for other works by this author on:
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Chapter 4: NMR Discrimination of Chiral Organic Compoundsp74-93ByJarosław JaźwińskiJarosław JaźwińskiInstitute of Organic Chemistry Polish Academy of Sciences, Poland [email protected]Search for other works by this author on:
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Chapter 5: A Brief Overview of the Chiral Agentsp94-120ByA. Brzezicki;A. BrzezickiaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, PolandbADAMED Pharma SA, Pieńków near Warsaw, PolandSearch for other works by this author on:P. GarbaczP. GarbaczaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland [email protected]Search for other works by this author on:
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Chapter 6: Nuclear Magnetic Shielding and Chiralityp121-157ByCynthia J. Jameson;Cynthia J. JamesonaDepartment of Chemistry, University of Illinois at Chicago, Chicago, 60607 Illinois, USA [email protected]Search for other works by this author on:Devin Sears;Devin SearsbCambrex Corp., Charles City, 50616 Iowa, USASearch for other works by this author on:Robert A. HarrisRobert A. HarriscDepartment of Chemistry, University of California, Berkeley, 94720 California, USA †Search for other works by this author on:
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Chapter 7: Antisymmetric Nuclear Magnetic Shielding as an Indicator of Molecular Chirality†p158-203ByP. GarbaczP. GarbaczFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland [email protected]Search for other works by this author on:
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Chapter 8: Chirality-sensitive Effects Induced by Antisymmetric Spin–Spin Coupling†p204-242ByP. Garbacz;P. GarbaczaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland [email protected]Search for other works by this author on:J. VaaraJ. VaarabNMR Research Unit, University of Oulu, P.O. Box 3000, FI-90014 Oulu, Finland [email protected]Search for other works by this author on:
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Chapter 9: Magnetochiral Dichroism in Nuclear Magnetic Resonance: Traveling Wave Enantioselective NMRp243-262ByManuel Donaire;Manuel DonaireaDepartamento de Física Teórica, Atómica y Óptica and IMUVA, Universidad de Valladolid, Paseo Belén 7, 47011 Valladolid, Spain, & Institut Néel – CNRS, Université Grenoble Alpes, Institut Néel, 38000, Grenoble, France [email protected]Search for other works by this author on:Geert L. J. A. RikkenGeert L. J. A. RikkenbLaboratoire National des Champs Magnétiques Intenses UPR3228 CNRS/EMFL/INSA/UGA/UPS, Toulouse & Grenoble, France [email protected]Search for other works by this author on:
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Chapter 10: Hyperpolarization Methods and Their Applications for the Investigation and Discrimination of Enantiomers in NMRp263-293ByA. Mames;A. MamesInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, PolandSearch for other works by this author on:M. Pietrzak;M. PietrzakInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland [email protected]Search for other works by this author on:T. RatajczykT. RatajczykInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland [email protected]Search for other works by this author on:
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