Chapter 4: NMR Discrimination of Chiral Organic Compounds Check Access

Chirality is a phenomenon of great importance in organic chemistry and biochemistry. Determining the optical purity of a compound obtained through synthesis or isolated from biological material, that is, determining the proportion of enantiomers, is essential in the study of the properties of the compound. Nuclear magnetic resonance spectroscopy (NMR) is one of the most convenient and widely used tools for studying organic compounds. However, unlike diastereomers, a routine NMR technique involving measurement in an achiral solvent and the absence of chiral auxiliaries does not discriminate between enantiomers. The survey reports exemplary auxiliary compounds that facilitate the transformation of enantiomer mixtures into mixtures of diastereomers, making them suitable for determining the optical purity of a compound or its configuration through NMR spectroscopy.