Chapter 9: Magnetochiral Dichroism in Nuclear Magnetic Resonance: Traveling Wave Enantioselective NMR Check Access

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for probing the electronic and nuclear structure surrounding a spin-carrying nucleus. Contrary to the established paradigm that NMR is insensitive to chirality, we show that, because of magneto-chiral anisotropy, NMR in a traveling-wave configuration is intrinsically sensitive to chirality and can differentiate between the two enantiomers of a chiral compound without the need for any auxiliary agents. We compute the NMR magneto-chiral anisotropy factor g_T associated with the nuclear spin transition induced by a traveling radio-frequency wave. We formulate g_T in terms of the parameters of two Hamiltonian models, one for diamagnetic and the other for paramagnetic chiral compounds. We also present a macroscopic model that establishes a relationship between g_T and the magnetochiral birefringence. In addition, for paramagnetic complexes, we relate g_T in NMR to its counterpart in electronic paramagnetic resonance. Quantitative estimates are given and we propose experimental setups to observe the predicted effect.