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Epigenetic Drug Discovery

Drug Discovery Series

Editor-in-chief:

Simon Ward, Cardiff University, UK

Series editors:

David Fox, Vulpine Science and Learning, UK

Ian Storer, AstraZeneca, UK

Gina Xiaojing Wang, Genetech, USA

Titles in the Series:

1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups

2: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 1

3: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 2

4: Accounts in Drug Discovery

5: New Frontiers in Chemical Biology

6: Animal Models for Neurodegenerative Disease

7: Neurodegeneration

8: G Protein-Coupled Receptors

9: Pharmaceutical Process Development

10: Extracellular and Intracellular Signaling

11: New Synthetic Technologies in Medicinal Chemistry

12: New Horizons in Predictive Toxicology

13: Drug Design Strategies: Quantitative Approaches

14: Neglected Diseases and Drug Discovery

15: Biomedical Imaging

16: Pharmaceutical Salts and Cocrystals

17: Polyamine Drug Discovery

18: Proteinases as Drug Targets

19: Kinase Drug Discovery

20: Drug Design Strategies: Computational Techniques and Applications

21: Designing Multi-Target Drugs

22: Nanostructured Biomaterials for Overcoming Biological Barriers

23: Physico-Chemical and Computational Approaches to Drug Discovery

24: Biomarkers for Traumatic Brain Injury

25: Drug Discovery from Natural Products

26: Anti-Inflammatory Drug Discovery

27: New Therapeutic Strategies for Type 2 Diabetes: Small Molecules

28: Drug Discovery for Psychiatric Disorders

29: Organic Chemistry of Drug Degradation

30: Computational Approaches to Nuclear Receptors

31: Traditional Chinese Medicine

32: Successful Strategies for the Discovery of Antiviral Drugs

33: Comprehensive Biomarker Discovery and Validation for Clinical Application

34: Emerging Drugs and Targets for Parkinson’s Disease

35: Pain Therapeutics; Current and Future Treatment Paradigms

36: Biotherapeutics: Recent Developments using Chemical and Molecular Biology

37: Inhibitors of Molecular Chaperones as Therapeutic Agents

38: Orphan Drugs and Rare Diseases

39: Ion Channel Drug Discovery

40: Macrocycles in Drug Discovery

41: Human-based Systems for Translational Research

42: Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics

43: Carbohydrates in Drug Design and Discovery

44: Drug Discovery for Schizophrenia

45: Cardiovascular and Metabolic Disease: Scientific Discoveries and New Therapies

46: Green Chemistry Strategies for Drug Discovery

47: Fragment-Based Drug Discovery

48: Epigenetics for Drug Discovery

49: New Horizons in Predictive Drug Metabolism and Pharmacokinetics

50: Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation

51: Nanomedicines: Design, Delivery and Detection

52: Synthetic Methods in Drug Discovery: Volume 1

53: Synthetic Methods in Drug Discovery: Volume 2

54: Drug Transporters: Role and Importance in ADME and Drug Development

55: Drug Transporters: Recent Advances and Emerging Technologies

56: Allosterism in Drug Discovery

57: Anti-aging Drugs: From Basic Research to Clinical Practice

58: Antibiotic Drug Discovery: New Targets and Molecular Entities

59: Peptide-based Drug Discovery: Challenges and New Therapeutics

60: Drug Discovery for Leishmaniasis

61: Biophysical Techniques in Drug Discovery

62: Acute Brain Impairment Through Stroke: Drug Discovery and Translational Research

63: Theranostics and Image Guided Drug Delivery

64: Pharmaceutical Formulation: The Science and Technology of Dosage Forms

65: Small-molecule Transcription Factor Inhibitors in Oncology

66: Therapies for Retinal Degeneration: Targeting Common Processes

67: Kinase Drug Discovery: Modern Approaches

68: Advances in Nucleic Acid Therapeutics

69: MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets

70: Emerging Drugs and Targets for Multiple Sclerosis

71: Cytotoxic Payloads for Antibody–Drug Conjugates

72: Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls

73: Anti-fibrotic Drug Discovery

74: Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology

75: Artificial Intelligence in Drug Discovery

76: New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs

77: Phenotypic Drug Discovery

78: Protein–Protein Interaction Regulators

79: The Medicinal Chemist’s Guide to Solving ADMET Challenges

80: Antiviral Discovery for Highly Pathogenic Emerging Viruses

81: Chemical Linkers in Antibody–Drug Conjugates (ADCs)

82: Drug Repurposing

83: Epigenetic Drug Discovery

How to obtain future titles on publication:

A standing order plan is available for this series. A standing order will bring delivery of each new volume immediately on publication.

For further information please contact:

Book Sales Department, Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK

Telephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247

Visit our website at books.rsc.org

Epigenetic Drug Discovery

Edited by

Ho Man Chan

AstraZeneca, USA

and

Cheryl H. Arrowsmith

University of Toronto and Princess Margaret Cancer Centre, Canada

Drug Discovery Series No. 83

Print ISBN: 978-1-83767-110-6

PDF ISBN: 978-1-83767-491-6

EPUB ISBN: 978-1-83767-492-3

Print ISSN: 2041-3203

Electronic ISSN: 2041-3211

A catalogue record for this book is available from the British Library

© The Royal Society of Chemistry 2024

All rights reserved

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