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New Developments in Mass Spectrometry
Glycoprotein Analysis
Edited by
Weston B Struwe
Weston B Struwe
University of Oxford
, UK
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Volume
15
Hardback ISBN:
978-1-83916-394-4
PDF ISBN:
978-1-83916-643-3
EPUB ISBN:
978-1-83916-644-0
Special Collection:
2024 eBook Collection
No. of Pages:
381
Publication date:
16 Oct 2024
About this book
Glycoproteins are central to numerous cellular processes and are among the most structurally complex biomolecules in nature. This unique complexity stems from variability in complex oligosaccharides that are located throughout the protein, a feature that is profoundly important for regulating biomolecular interactions but also makes glycoproteins difficult to study. As such, glycoprotein analysis entails a range of techniques to bridge the knowledge gap between glycoprotein structure and biological function.
This book serves as an authoritative guide to glycoprotein analysis, written by internationally recognised experts in the field and discussed in the context of real-world applications across the life sciences. It provides a wide-ranging assessment of the modern methods, from those used to characterise glycoprotein structure, to approaches proficient in uncovering the molecular mechanisms by which they function as well as those capable of measuring structural dynamics and macromolecular assembly. These methods differ to a large extent and include mass spectrometry, glycan/lectin arrays, nuclear magnetic resonance, infrared spectroscopy, scanning probe microscopy and high-performance liquid chromatography. Equally important are computational techniques, including molecular dynamics and bioinformatics, which are also covered and discussed in the wider context of glycoprotein analysis.
Glycobiology is indeed a rapidly growing field and the development of advanced tools for glycoproteins analysis has been enabled by researchers from different backgrounds working to overcome long-standing analytical challenges and biological questions involving glycosylation. This book is intended to aid academic and professional researchers at various levels of their career to gain a deeper appreciation of cutting-edge methods in glycoprotein analysis and their applications in biomolecular research, biotherapeutic development, structural biology and biophysical chemistry.
Glycoprotein Analysis, Royal Society of Chemistry, 2024.
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Glycoprotein Analysis
$280.00
Table of contents
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Chapter 1: Overview of Glycosylation Studies of SARS-CoV-2p1-28ByLauren E. Pepi;Lauren E. PepiComplex Carbohydrate Research Center, University of Georgia,Athens, GA 30602,USASearch for other works by this author on:Asif Shajahan;Asif ShajahanComplex Carbohydrate Research Center, University of Georgia,Athens, GA 30602,USASearch for other works by this author on:Anne S. Gleinich;Anne S. GleinichComplex Carbohydrate Research Center, University of Georgia,Athens, GA 30602,USASearch for other works by this author on:Christian Heiss;Christian HeissComplex Carbohydrate Research Center, University of Georgia,Athens, GA 30602,USASearch for other works by this author on:Parastoo AzadiParastoo AzadiComplex Carbohydrate Research Center, University of Georgia,Athens, GA 30602,USAE-mail: [email protected]Search for other works by this author on:
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Chapter 2: Methods and Materials for Studying Proteoglycans and Glycosaminoglycansp29-60ByRichard Karlsson;Richard KarlssonCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen,Blegdamsvej 3, DK-2200 Copenhagen N,DenmarkSearch for other works by this author on:Magnus N. Grønset;Magnus N. GrønsetCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen,Blegdamsvej 3, DK-2200 Copenhagen N,DenmarkSearch for other works by this author on:Christine Chuang;Christine ChuangDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen,DenmarkSearch for other works by this author on:Joseph A. Hippensteel;Joseph A. HippensteelDepartment of Medicine, University of Colorado Anschutz Medical Campus,Aurora, Colorado,USASearch for other works by this author on:Rebecca L. MillerRebecca L. MillerCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen,Blegdamsvej 3, DK-2200 Copenhagen N,DenmarkE-mail: [email protected]Search for other works by this author on:
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Chapter 3: Glycoprotein Characterization by Nuclear Magnetic Resonance Spectroscopyp61-75ByA. I. Manzano;A. I. ManzanoDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Univ. Complutense de Madrid,Avd. Complutense s/n, 24040 Madrid,Spain†Search for other works by this author on:D. Heras-Márquez;D. Heras-MárquezDepartamento de Bioquímica, Facultad de Ciencias Químicas, Univ. Complutense de Madrid,Avd. Complutense s/n, 24040 Madrid,Spain†Search for other works by this author on:S. García-Linares;S. García-LinaresDepartamento de Bioquímica, Facultad de Ciencias Químicas, Univ. Complutense de Madrid,Avd. Complutense s/n, 24040 Madrid,SpainSearch for other works by this author on:A. CanalesA. CanalesDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Univ. Complutense de Madrid,Avd. Complutense s/n, 24040 Madrid,SpainE-mail: [email protected]Search for other works by this author on:
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Chapter 4: Cold-ion Spectroscopy of Carbohydratesp76-94ByMarc Safferthal;Marc SafferthalDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin,Altensteinstraße 23a, 14195 Berlin,GermanyDepartment of Molecular Physics, Fritz Haber Institute of the Max Planck Society,Faradayweg 4-6, 14195 Berlin,GermanySearch for other works by this author on:Łukasz Polewski;Łukasz PolewskiDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin,Altensteinstraße 23a, 14195 Berlin,GermanyDepartment of Molecular Physics, Fritz Haber Institute of the Max Planck Society,Faradayweg 4-6, 14195 Berlin,GermanySearch for other works by this author on:Chun-Wei Chang;Chun-Wei ChangDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin,Altensteinstraße 23a, 14195 Berlin,GermanyDepartment of Molecular Physics, Fritz Haber Institute of the Max Planck Society,Faradayweg 4-6, 14195 Berlin,GermanySearch for other works by this author on:Kim Greis;Kim GreisDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin,Altensteinstraße 23a, 14195 Berlin,GermanyDepartment of Molecular Physics, Fritz Haber Institute of the Max Planck Society,Faradayweg 4-6, 14195 Berlin,GermanySearch for other works by this author on:Kevin PagelKevin PagelDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin,Altensteinstraße 23a, 14195 Berlin,GermanyDepartment of Molecular Physics, Fritz Haber Institute of the Max Planck Society,Faradayweg 4-6, 14195 Berlin,GermanyE-mail: [email protected]Search for other works by this author on:
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Chapter 5: Cracking the Glycome with the Sweet Tooth of Nature: Overview and Outlook of Lectin Microarray Technologyp95-117ByRui Qin;Rui QinDepartment of Chemistry, University of Alberta,Edmonton, AB, T6G 2G2,CanadaSearch for other works by this author on:Lara K. MahalLara K. MahalDepartment of Chemistry, University of Alberta,Edmonton, AB, T6G 2G2,CanadaE-mail: [email protected]Search for other works by this author on:
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Chapter 6: O-Glycoproteomics: Methods, Challenges, and New Opportunitiesp118-162ByStacy A. MalakerStacy A. MalakerSearch for other works by this author on:
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Chapter 7: Use of Ion Mobility for the Structural Identification of Glycansp163-219ByDavid J. HarveyDavid J. HarveyDepartment of Biochemistry, University of Oxford,Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU,UKE-mail: [email protected]Search for other works by this author on:
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Chapter 8: Advanced Activation Techniques for the Determination of Glycan Structures Using Tandem Mass Spectrometryp220-259ByC. Lin;C. LinCenter for Biomedical Mass Spectrometry, Boston University Chobanian & Avedisian School of Medicine,670 Albany St., Rm. 511, Boston, MA 02118,USASearch for other works by this author on:C. E. CostelloC. E. CostelloCenter for Biomedical Mass Spectrometry, Boston University Chobanian & Avedisian School of Medicine,670 Albany St., Rm. 511, Boston, MA 02118,USAE-mail: [email protected]Search for other works by this author on:
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Chapter 9: Native Mass Spectrometry of Glycoproteinsp260-278ByDi Wu;Di WuKavli Institute for Nanoscience Discovery, University of Oxford,Oxford,UKSearch for other works by this author on:Weston B. StruweWeston B. StruweKavli Institute for Nanoscience Discovery, University of Oxford,Oxford,UKSearch for other works by this author on:
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Chapter 10: O-GalNAc Glycomics by LC–MS/MSp279-299ByKay-Hooi KhooKay-Hooi KhooSearch for other works by this author on:
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Chapter 11: Application of HDX–MS for the Structural Characterization of Glycoproteinsp300-314ByMiklos GuttmanMiklos GuttmanUniversity of Washington Medicine Diabetes Institute, University of Washington,Seattle, WA,USAE-mail: [email protected]Search for other works by this author on:
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Chapter 12: Reconstructing Glycosylation: How to Rebuild Glycoproteins by Molecular Dynamics-generated 3D Librariesp315-328ByCarl A. Fogarty;Carl A. FogartyDepartment of Chemistry and Hamilton Institute, Maynooth University,Maynooth,IrelandSearch for other works by this author on:Callum M Ives;Callum M IvesDepartment of Chemistry and Hamilton Institute, Maynooth University,Maynooth,IrelandSearch for other works by this author on:Ojas Singh;Ojas SinghDepartment of Chemistry and Hamilton Institute, Maynooth University,Maynooth,IrelandSearch for other works by this author on:Elisa FaddaElisa FaddaSchool of Biological Sciences, University of Southampton,Southampton,United KingdomE-mail: [email protected]Search for other works by this author on:
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Chapter 13: High-resolution Imaging of Glycans by Scanning Tunnelling Microscopy Enabled by Electrospray Ion Beam Deposition (ESIBD)p329-354ByStephan Rauschenbach;Stephan RauschenbachDepartment of Chemistry, University of Oxford, Kavli Institute for Nanoscience Discovery,Oxford,UKE-mail: [email protected]Search for other works by this author on:Marko Grabarics;Marko GrabaricsDepartment of Chemistry, University of Oxford, Kavli Institute for Nanoscience Discovery,Oxford,UKSearch for other works by this author on:Martina Delbianco;Martina DelbiancoMax Planck Institute of Colloids and Interfaces,Potsdam,GermanySearch for other works by this author on:Juan Cortes;Juan CortesLAAS-CNRS, Université de Toulouse,CNRS, Toulouse,FranceSearch for other works by this author on:Christian Schön;Christian SchönMax Planck Institute for Solid State Research,Stuttgart,GermanySearch for other works by this author on:Nathalie Tarrat;Nathalie TarratCEMES-CNRS,Toulouse,FranceSearch for other works by this author on:Xu Wu;Xu WuBeijing Institute of Technology,Beijing,ChinaSearch for other works by this author on:Kelvin AnggaraKelvin AnggaraMax Planck Institute for Solid State Research,Stuttgart,GermanySearch for other works by this author on:
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