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SARS-CoV-19 and its variants ranging from coronavirus to the omicron have composed the recent pandemic of the century, placing the world at a standstill. Millions of individuals worldwide have been negatively impacted by the Covid-19 pandemic. To combat the catastrophe of Covid-19, lessons learned from the previous pandemics have also been implemented. Nevertheless, advanced diagnostics, treatments, and vaccinations for SARS-Cov-2 were required. In this regard, nanotechnology has played a prominent role that has led to faster development of treatment modalities. This critical review discusses the prominent role played by various nanomaterials in dealing with the SARS-CoV-19 outbreak and its treatment. Nanotechnology-based contemporary strategies can pave a path for the future, wherein nano-based materials can be used preferentially in combating global infections.

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