Chapter 6: Stability of Metal Complexes and Ligand Substitution Reactions

In this chapter, the necessary basics (solvents, chemical equilibria, and definitions of acids and bases) are briefly explained before the stability of metal complexes and ligand substitution reactions are discussed. Then, the formation and stepwise formation constants, which are indicators of the stability of metal complexes, are explained. The effects of the Irving–Williams series and chelate effects, which are necessary for discussing the stability of metal complexes, are also explained. Finally, ligand substitution reactions are introduced as one of the most typical reactions of metal complexes. From the concept of substitutional lability and inertness by Taube, the reaction mechanisms of actual ligand substitution reactions, the water exchange rates of the aqua metal complexes, and the trans effect are described.