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A blood purification device with a membrane is a crucial medical tool utilized in the treatment of kidney failure and other blood-related ailments. This device employs hollow-fiber membranes as a means of separating waste products, toxins, and surplus fluids from the blood by means of selective permeability, while simultaneously preserving beneficial substances and blood cells. The design and manufacture of the membrane equipment play a crucial role in ensuring its effectiveness. This chapter mainly describes the processing of hollow-fiber membranes used for blood purification and the assembly principle of the purification devices.

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