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The hemocompatibility of blood-contacting materials, e.g. blood purification membranes, is responsible for many activated cascades, inflammations, and side effects. Surface modifications that can minimize the activation of blood defense and significantly reduce and prevent thrombosis have been recognized as a significant strategy to improve and upgrade the hemocompatibility of versatile blood-contacting materials. In this chapter, technologies and recent developments in fabricating bioinert hydrophilic coatings, bioactive antithrombogenic coatings, superhydrophobic coatings, and lubricant-infused coatings on the surface of blood-contacting materials to improve their hemocompatibility are summarized.

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