Chapter 2: Fluorescent Probes Developed for Low-cost Small-molecule Diagnostics
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Published:11 Dec 2024
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Special Collection: 2024 eBook CollectionSeries: Detection Science Series
Q. Wang, Y. Zhu, Y. Qin, and L. Wu, in Low-cost Diagnostics
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The adoption of small-molecule biomarker-driven approaches in clinical decision-making has substantially enhanced the safety and effectiveness of specific therapeutic interventions. Fluorescent probes have gained significant recognition as essential chemical tools for detecting small molecules. Small-molecule fluorescent probes offer numerous benefits, including cost-effectiveness, ease of synthesis and storage, and considerable flexibility in probe design. Importantly, they typically induce minimal disturbance to the native target within complex environments. To date, hundreds of targeted small molecules are in surveillance pipelines. This chapter provides a brief overview of the recently discovered four categories and ten types of low-cost small molecules and their corresponding indicators in diagnosing cancers, diabetes mellitus, hypertension, depressive disorder, etc.