Chapter 6: Smell of Dopamine in Schizophrenia: Towards Drug Discovery
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Published:06 Dec 2024
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Special Collection: 2024 eBook CollectionSeries: Drug Discovery Series
H. Zhou, Q. Li, and D. Yin, in Drug Discovery for Schizophrenia
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In this chapter, we will propose the dopamine hypothesis of schizophrenia from the angle of the olfactory system, in light of recent evidence highlighting the importance of nasal dopamine in regulating activity of olfactory sensory neurons that play critical roles in modulating higher brain functions. We will then discuss the potential contribution of olfactory dysfunction to schizophrenia, and the possibility of using the olfactory system as a translational platform for mechanistic study and drug development of schizophrenia. Lastly, we will summarize the prospect of intranasal administration as a novel and efficient route to target the central nervous system.