Chapter 2: Colorimetric Paper-based Point-of-care Testing for Disease Biomarkers
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Published:20 Dec 2024
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Special Collection: 2024 eBook CollectionSeries: Detection Science Series
S. Alom, F. Ali, and D. Kathuria, in Sensing Materials and Devices for Biomarkers, ed. V. Mutreja, D. Kathuria, S. Sareen, and J. Park, Royal Society of Chemistry, 2024, vol. 28, ch. 2, pp. 37-94.
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Point-of-care testing (POCT) via paper-based colorimetric sensors allows for on-site testing, with biomarker detection visible to the naked eye within minutes, leading to better health management. In this chapter, we emphasise the fundamentals, fabrication techniques and development of paper-based colorimetric sensors. The use of POCT paper-based colorimetric sensors for the diagnosis of biomarkers associated with various diseases such as COVID-19, HIV, dengue, malaria, diabetes, cancer, etc. has been discussed in detail. The application of paper-based colorimetric sensors in the detection of fertility and pregnancy has also been highlighted. The unique properties of paper have also been summarised in order to create cost-effective, simple and easy-to-use devices. In the end, the challenges and emerging opportunities of POCT, paper-based colorimetric sensors have also been discussed. This chapter paves the way for research in paper-based colorimetric sensors.