Characterisation of Drug Nanocarriers
Nanotechnology has the potential to solve many unmet, urgent healthcare requirements. However, bridging the translational gap between lab and clinic for nanodrugs is still challenging, and there is limited guidance on regulatory-relevant information and approaches.The main aim of this book is to provide guidance on characterization of drug carrier properties and efficacy required for regulatory acceptance of nanomaterials for their use in medicine.This book provides a comprehensive overview of drug loading and delivery nanocarriers, including their characteristics, methodologies and techniques to evaluate the association and interaction of the drug with different nanocarriers.
Characterisation of Drug Nanocarriers, Royal Society of Chemistry, 2024.
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Chapter 1: Introduction to Nanomedicine and Nanopharmaceuticalsp1-33ByM. Beus;M. BeusaInstitute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, Croatia [email protected]; [email protected]Search for other works by this author on:L. Božičević;L. BožičevićaInstitute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, CroatiaSearch for other works by this author on:I. Mamić;I. MamićbUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmacology, Domagojeva 2, 10 000 Zagreb, CroatiaSearch for other works by this author on:P. Turčić;P. TurčićbUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmacology, Domagojeva 2, 10 000 Zagreb, CroatiaSearch for other works by this author on:N. Ventosa;N. VentosacInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpaindCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:E. González-Mira;E. González-MiracInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpaindCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:M. KöberM. KöbercInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpaindCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:
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Chapter 2: Solid Nanocarriers and Bioconjugation Strategies for Efficient In Vivo Drug Transportp34-90ByS. Iqbal;S. IqbalInstitute of Inorganic Chemistry and Materials, University of Cologne, Greinstraße 6, 50939, Cologne, GermanySearch for other works by this author on:S. Ilyas;S. IlyasInstitute of Inorganic Chemistry and Materials, University of Cologne, Greinstraße 6, 50939, Cologne, GermanySearch for other works by this author on:S. MathurS. MathurInstitute of Inorganic Chemistry and Materials, University of Cologne, Greinstraße 6, 50939, Cologne, Germany [email protected]Search for other works by this author on:
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Chapter 3: Micellar Nanocarriersp91-119ByS. García-Gallego;S. García-GallegoaUniversity of Alcala, Department of Organic and Inorganic Chemistry, Faculty of Sciences, and Research Institute in Chemistry “Andrés M. del Río” (IQAR), 28801 Alcalá de Henares, Spain [email protected]bInstitute Ramón y Cajal for Health Research (IRYCIS), 28034 Madrid, SpaincNetworking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, SpainSearch for other works by this author on:M.F. OttavianiM.F. OttavianidDiSPeA, Via Sant’Andrea 34, 61029 Urbino, ItalySearch for other works by this author on:
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Chapter 4: Nanovesiclesp120-152ByN. Pujol-Solé;N. Pujol-SoléaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpainSearch for other works by this author on:L. Ferrer-Tasies;L. Ferrer-TasiesbNanomol Technologies S.L., 08193 Cerdanyola del Vallès, SpainSearch for other works by this author on:J. Tomsen-Melero;J. Tomsen-MeleroaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpaincCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:A. Carreño;A. CarreñoaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpainSearch for other works by this author on:C. Castellar-Álvarez;C. Castellar-ÁlvarezaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpainbNanomol Technologies S.L., 08193 Cerdanyola del Vallès, SpaincCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:M. Alcaina-Hernando;M. Alcaina-HernandoaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpainbNanomol Technologies S.L., 08193 Cerdanyola del Vallès, SpaincCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:N. Ventosa;N. VentosaaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, SpaincCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:E. González-Mira;E. González-MiraaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, Spain [email protected]cCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:M. KöberM. KöberaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, Cerdanyola del Vallès, Spain [email protected]cCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, SpainSearch for other works by this author on:
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Chapter 5: Polymer-based Nanovesiclesp153-178ByS. Ercelen Ceylan;S. Ercelen CeylanaUniversity of Health Sciences, Hamidiye Faculty of Medicine, Department of Biophysics, Istanbul, Turkey [email protected]bTUBITAK Marmara Research Center, Life Sciences Vice Presidency, Kocaeli, TurkeySearch for other works by this author on:B. Bulkurcuoğlu;B. BulkurcuoğlubTUBITAK Marmara Research Center, Life Sciences Vice Presidency, Kocaeli, TurkeycInstitute of Biotechnology, Gebze Technical University, Kocaeli, TurkeySearch for other works by this author on:O. Zaichenko;O. ZaichenkodLviv Polytechnic National University, Department of Organic Chemistry, Lviv, UkraineSearch for other works by this author on:N. Mitina;N. MitinadLviv Polytechnic National University, Department of Organic Chemistry, Lviv, UkraineSearch for other works by this author on:Kh. Harhay;Kh. HarhaydLviv Polytechnic National University, Department of Organic Chemistry, Lviv, UkraineSearch for other works by this author on:N. Finiuk;N. FiniukeInstitute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, UkraineSearch for other works by this author on:V.M. GaramusV.M. GaramusfHelmholtz-Zentrum Hereon, Geesthacht, GermanySearch for other works by this author on:
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Chapter 6: Polymer-based Nanocapsulesp179-208ByEleni K. Efthimiadou;Eleni K. EfthimiadouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, Greece [email protected]Search for other works by this author on:Sara Seriah;Sara SeriahInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Danai Prokopiou;Danai ProkopiouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Anastasia Stavropoulou;Anastasia StavropoulouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Athina Papadopoulou;Athina PapadopoulouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Sofia Nikolopoulou;Sofia NikolopoulouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Evangelia Tsitsou;Evangelia TsitsouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Maria TheodosiouMaria TheodosiouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:
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Chapter 7: Dendrimersp209-236ByM. Müllerová;M. MüllerováInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Prague, Czech RepublicSearch for other works by this author on:T. StrašákT. StrašákInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Prague, Czech Republic [email protected]Search for other works by this author on:
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Chapter 8: Metal-based Nanocarriersp237-272ByEleni K. Efthimiadou;Eleni K. EfthimiadouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, Greece [email protected]Search for other works by this author on:Danai Prokopiou;Danai ProkopiouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Anastasia Stavropoulou;Anastasia StavropoulouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Athina Papadopoulou;Athina PapadopoulouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Sofia Nikolopoulou;Sofia NikolopoulouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Evangelia Tsitsou;Evangelia TsitsouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:Maria TheodosiouMaria TheodosiouInorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, GreeceSearch for other works by this author on:
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Chapter 9: Graphene-based Multifunctional Nanomaterials for Biomedical Applicationsp273-296ByAna Catarina Almeida;Ana Catarina AlmeidaaTEMA - Centre for Mechanical Technology and Automation, Mechanical Engineering Department, University of Aveiro, 3810-193 Aveiro, PortugalbIntelligent Systems Associate Laboratory, 3810-193 Aveiro, PortugalSearch for other works by this author on:Carla I. M. Santos;Carla I. M. SantoscCentro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisboa, PortugaldLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalSearch for other works by this author on:Enrico Catalano;Enrico CatalanoeScuola Normale Superiore, P.za dei Cavalieri, 7, 56126 Pisa, ItalySearch for other works by this author on:M. Graça P. M. S. Neves;M. Graça P. M. S. NevesdLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalSearch for other works by this author on:Gil GonçalvesGil GonçalvesaTEMA - Centre for Mechanical Technology and Automation, Mechanical Engineering Department, University of Aveiro, 3810-193 Aveiro, Portugal [email protected]bIntelligent Systems Associate Laboratory, 3810-193 Aveiro, PortugalSearch for other works by this author on:
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Chapter 10: Targeted Nanocarriersp297-326ByD. B. Yalcinkaya;D. B. YalcinkayaaYeditepe University, Department of Biophysics, Kayisdagi St., Istanbul, 34755, TurkeySearch for other works by this author on:S. Dogan;S. DoganbYeditepe University, Department of Medical Biology, Kayisdagi St., Istanbul, 34755, TurkeySearch for other works by this author on:V. C. Ozalp;V. C. OzalpcAtilim University, Department of Medical Biology, Kizilcasar St., Ankara, 06830, TurkeySearch for other works by this author on:B. Guvenc TunaB. Guvenc TunaaYeditepe University, Department of Biophysics, Kayisdagi St., Istanbul, 34755, Turkey [email protected]; [email protected]Search for other works by this author on:
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Chapter 11: Genetically Engineered Protein Nano-carriers: Viral Capsids and Cage Proteinsp327-352BySenem Şen;Senem ŞenaUNAM – National Nanotechnology Research Center, Bilkent University, 06800 Ankara, TurkeybInstitute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, TurkeySearch for other works by this author on:Aslı Semerci;Aslı SemerciaUNAM – National Nanotechnology Research Center, Bilkent University, 06800 Ankara, TurkeybInstitute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, TurkeySearch for other works by this author on:Melis Karaca;Melis KaracaaUNAM – National Nanotechnology Research Center, Bilkent University, 06800 Ankara, TurkeybInstitute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, TurkeySearch for other works by this author on:Urartu Özgür Şafak ŞekerUrartu Özgür Şafak ŞekeraUNAM – National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey [email protected]bInstitute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, TurkeySearch for other works by this author on:
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Chapter 12: Understanding the GxP Requirements During Different Phases of Nanopharmaceutical Developmentp353-370ByI. Capjak;I. CapjakaCroatian Institute for Transfusion Medicine, Petrova 3, Zagreb, Croatia [email protected]bInstitute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, CroatiaSearch for other works by this author on:I. Vinković VrčekI. Vinković VrčekbInstitute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, CroatiaSearch for other works by this author on:
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