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Drug Discovery Series
DNA-encoded Library Technology for Drug Discovery
Edited by
Casey J Krusemark;
Casey J Krusemark
Purdue University, USA
https://orcid.org/0000-0003-2964-3520
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Volume
85
Hardback ISBN:
978-1-78801-487-8
PDF ISBN:
978-1-78801-603-2
EPUB ISBN:
978-1-83916-055-4
Special Collection:
2025 eBook Collection
Series:
Drug Discovery Series
No. of Pages:
176
Publication date:
21 Feb 2025
About this book
DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.
This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.
A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.
DNA-encoded Library Technology for Drug Discovery, Royal Society of Chemistry, 2025.
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Digital access
$210.00
Print format
DNA-encoded Library Technology for Drug Discovery
$210.00
Table of contents
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Chapter 1: Affinity-based DEL Selections with Different Target Types: Overview and Achievementsp1-16ByQiuxia Chen;Qiuxia ChenHitGen Inc., No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, ChinaSearch for other works by this author on:David I. IsraelDavid I. IsraelHitGen Inc., No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, China [email protected]Search for other works by this author on:
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Chapter 2: DNA-encoded Library Machine Learning Applicationsp17-40ByEric A. SigelEric A. SigelSignel IX LLC, Belmont, MA 02478, USA [email protected]Search for other works by this author on:
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Chapter 3: Solid-phase DNA-encoded Library Technologyp41-62ByJuan Hu;Juan HuaDepartment of Pharmaceutical Sciences, University of California, Irvine, California 92697, USASearch for other works by this author on:John P. Burdick;John P. BurdickaDepartment of Pharmaceutical Sciences, University of California, Irvine, California 92697, USASearch for other works by this author on:Brian M. PaegelBrian M. PaegelaDepartment of Pharmaceutical Sciences, University of California, Irvine, California 92697, USAbDepartments of Chemistry & Biomedical Engineering, University of California, Irvine, California 92697, USA [email protected]Search for other works by this author on:
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Chapter 4: Assays of DNA-encoded Libraries Against Protein Targets on and Within Living Cellsp63-86BySiavash Shahbazi Nia;Siavash Shahbazi NiaDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University and Purdue University Center for Cancer Research, 575 Stadium Mall Drive, West Lafayette, Indiana 47906, USASearch for other works by this author on:Casey J. KrusemarkCasey J. KrusemarkDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University and Purdue University Center for Cancer Research, 575 Stadium Mall Drive, West Lafayette, Indiana 47906, USA [email protected]Search for other works by this author on:
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Chapter 5: On-DNA Medicinal Chemistry: Focused Libraries, Fragment Expansion, and Hit Optimisationp87-118ByH. A. Stanway-Gordon;H. A. Stanway-GordonCancer Research Horizons Therapeutic Innovation Newcastle Drug Discovery Group, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, UKSearch for other works by this author on:M. J. WaringM. J. WaringCancer Research Horizons Therapeutic Innovation Newcastle Drug Discovery Group, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, UK [email protected]Search for other works by this author on:
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Chapter 6: DNA-encoded Libraries with Covalent Warheadsp119-133BySixiu Liu;Sixiu LiuaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinabUniversity of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, ChinaSearch for other works by this author on:Rui Jin;Rui JinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinaSearch for other works by this author on:Zhiqiang Duan;Zhiqiang DuanaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinaSearch for other works by this author on:Xiaojie LuXiaojie LuaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinabUniversity of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China [email protected]Search for other works by this author on:
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Chapter 7: Application of DELs for E3 Ligase Ligand Discovery and Targeted Protein Degradationp134-156ByMarie L. Malone;Marie L. MaloneNurix Therapeutics, 1700 Owens STE 205, San Francisco, 94158, USASearch for other works by this author on:Nicholas A. Sanchez;Nicholas A. SanchezNurix Therapeutics, 1700 Owens STE 205, San Francisco, 94158, USASearch for other works by this author on:Stacy L. Hu;Stacy L. HuNurix Therapeutics, 1700 Owens STE 205, San Francisco, 94158, USASearch for other works by this author on:Christopher B. PhelpsChristopher B. PhelpsNurix Therapeutics, 1700 Owens STE 205, San Francisco, 94158, USA [email protected]Search for other works by this author on:
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