Chapter 6: DNA-encoded Libraries with Covalent Warheads Check Access

Currently, research on the application of covalent DNA-encoded compound libraries (covalent DELs, or CoDELs) is experiencing rapid growth, with numerous advancements and diverse applications. CoDELs provide several advantages over traditional discovery methods for discovering covalent inhibitors and have successfully overcome some of their limitations. This section provides an overview of the current state and major applications in CoDELs. It will briefly introduce the design principles and selection methods, and provide a detailed analysis of the compound properties exhibited by these libraries.