DNA-encoded Libraries with Covalent Warheads

Liu, Sixiu; Jin, Rui; Duan, Zhiqiang; Lu, Xiaojie

doi:10.1039/9781788016032-00119

Skip Nav Destination

Drug Discovery Series

DNA-encoded Library Technology for Drug Discovery

Edited by

Volume

DOI:

https://doi.org/10.1039/9781788016032

Hardback ISBN:

978-1-78801-487-8

PDF ISBN:

978-1-78801-603-2

EPUB ISBN:

978-1-83916-055-4

Special Collection: 2025 eBook Collection

Series: Drug Discovery Series

No. of Pages:

176

Publication date:

21 Feb 2025

Book Chapter

Chapter 6: DNA-encoded Libraries with Covalent Warheads

Sixiu Liu

aState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

bUniversity of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China

Search for other works by this author on:

This Site

PubMed

Google Scholar

;

Rui Jin

aState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

Search for other works by this author on:

This Site

PubMed

Google Scholar

;

Zhiqiang Duan

aState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

Search for other works by this author on:

This Site

PubMed

Google Scholar

;

Xiaojie Lu

aState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

bUniversity of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China [email protected]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Doi:

https://doi.org/10.1039/9781788016032-00119

Published:

21 Feb 2025
Special Collection: 2025 eBook Collection

Series: Drug Discovery Series

Page range:

119 - 133

Currently, research on the application of covalent DNA-encoded compound libraries (covalent DELs, or CoDELs) is experiencing rapid growth, with numerous advancements and diverse applications. CoDELs provide several advantages over traditional discovery methods for discovering covalent inhibitors and have successfully overcome some of their limitations. This section provides an overview of the current state and major applications in CoDELs. It will briefly introduce the design principles and selection methods, and provide a detailed analysis of the compound properties exhibited by these libraries.

You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.

Don't already have an account? Register

Log in

Chapter 6: DNA-encoded Libraries with Covalent Warheads

Log in

Institutional access

My account

Digital access

This Feature Is Available To Subscribers Only