Chapter 13: Lactobacilli as Gut Modulators: Established Applications

Lactobacillus, a diverse group of bacterial species residing in the gut microflora, plays a pivotal role in human health. These beneficial bacteria boost immunity, secrete essential metabolites, and contribute significantly to wellbeing. As key components of probiotics, Lactobacillus species support early-life gut colonization, maintain bile secretion, and help manage inflammation, hypertension, and even certain cancers. Probiotics enriched with Lactobacillus are crucial for balancing gut microbiota, promoting overall health, and bolstering immune function. These species also exhibit antimicrobial properties, notably producing bacteriocins, which act as natural antibiotics. This underscores the value of incorporating fermented foods like kimchi into our diets for gut health. Lactobacillus species also aid in managing inflammatory bowel conditions like irritable bowel syndrome and inflammatory bowel disease (IBD). Their ability to maintain gut pH and strengthen the gut barrier further emphasizes their importance in gut health. The extensive use of lactic acid bacteria (LAB), including Lactobacillus, in probiotics highlights their significance in preventing and managing gut-related illnesses. LAB contribute to various health aspects, including inflammation control, cancer prevention, overall wellbeing, and immune system support. Additionally, LAB assists in nutrient absorption by breaking down carbohydrates, aiding in the production of essential vitamins. This chapter explores the diverse functions of LAB, underlining their vital role in maintaining gut health. It also opens avenues for their potential use in clinical therapies to enhance human wellbeing.