Salmonella Biofilms: Formation, Resistance, and Therapeutics
Up to 80% of chronic and recurrent human bacterial infections are caused by bacterial biofilms, which are extremely hard to cure. Salmonella is an especially interesting pathogen because of its ability to cause diseases through a variety of mechanisms and form complex communities in biofilms.
Due to the difficulty of treatment, investigation of alternatives to conventional antibiotics is an important direction of research in combating biofilm formation including natural products, nanoparticles, matrix degrading enzymes or combinatorial enzymes, quorum quenching, and novel combinations with other therapies such as PDT and surgical intervention.
This book covers the process of Salmonella infection and mechanisms of biofilm formation, current and emerging therapeutic management strategies against Salmonella biofilms as well as the limitations of existing treatment options. It also covers the complex relationship between biofilm infection and other co-morbidities.
The book will be of interest to advanced students and researchers interested in antimicrobial resistance, bacteriology, antibiotic drug development, and related research.
Salmonella Biofilms: Formation, Resistance, and Therapeutics, Royal Society of Chemistry, 2025.
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Chapter 1: Biofilm: A Life for Microorganisms with Basic Biofilm Principlesp1-33ByMrunal PatilMrunal PatilAix Marseille Université, CNRS, CINaM UMR 7325, Campus de Luminy, Case 913, 13288 Marseille Cedex 09, France [email protected]Search for other works by this author on:
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Chapter 2: Salmonella Infections with Biofilms in Developed and Developing Nationsp34-45ByDhruti Sundar Pattanayak;Dhruti Sundar PattanayakaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, IndiaSearch for other works by this author on:Dharm Pal;Dharm PalaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, India [email protected]Search for other works by this author on:Venkteshwar Yadav;Venkteshwar YadavaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, IndiaSearch for other works by this author on:Aditya UpadhyayAditya UpadhyaybDepartment of Biotechnology, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, IndiaSearch for other works by this author on:
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Chapter 3: Uncovering the Co-relationship Between Salmonella Biofilm Infections and Other Morbiditiesp46-78ByRupal Dhariwal;Rupal DhariwalaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Khemraj Deshmukh;Khemraj DeshmukhbDepartment of Biomedical Engg, Mody University of Science and Technology, Lakshmangarh, Sikar, Rajasthan, India [email protected]Search for other works by this author on:Aditya Upadhyay;Aditya UpadhyaycDepartment of Biotechnology, National Institute of Technology, Raipur-492010 (CG), IndiaSearch for other works by this author on:Nil Patil;Nil PatilaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Bindiya Upadhyay;Bindiya UpadhyayaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Komal Janiyani;Komal JaniyaniaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Harjeet Singh;Harjeet SinghdNarnarayan Shastri Institute of Technology-Institute of Forensic Science and Cyber Security (NSIT-IFSCS), Jetalpur, Ahmedabad, Gujarat, 382427, IndiaSearch for other works by this author on:Mukul JainMukul JainaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:
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Chapter 4: Antibiotic Therapy for Salmonella Biofilm Disruptionp79-92ByDharm Pal;Dharm PalaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, India [email protected]Search for other works by this author on:Venkteshwar Yadav;Venkteshwar YadavaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, IndiaSearch for other works by this author on:Dhananjay Singh;Dhananjay SinghbDepartment of Chemical Engineering, Institute of Engineering & Technology, Lucknow 226021, Uttar Pradesh, IndiaSearch for other works by this author on:A. B. SoniA. B. SoniaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, IndiaSearch for other works by this author on:
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Chapter 5: Enzymatic Drug Therapy for Salmonella Biofilm Disruptionp93-102ByVenkteshwar Yadav;Venkteshwar YadavaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, IndiaSearch for other works by this author on:Dharm Pal;Dharm PalaDepartment of Chemical Engineering, National Institute of Technology Raipur, Raipur 492010, Chhattisgarh, India [email protected]Search for other works by this author on:Sushil Kumar;Sushil KumarbDepartment of Chemical Engineering, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh 211004, IndiaSearch for other works by this author on:Nikhil PrakashNikhil PrakashcDepartment of Chemical Engineering, Sant Longowal Institute of Engineering and Technology, Longowal (S.L.I.E.T.), Sangrur-148106, Punjab, IndiaSearch for other works by this author on:
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Chapter 6: Secondary Metabolites and Peptide Drug Therapy for Salmonella Biofilm Disruptionp103-122ByAditya Upadhyay;Aditya UpadhyayaDepartment of Biotechnology, National Institute of Technology, Raipur-492010 (CG), IndiaSearch for other works by this author on:Priyanka Singh;Priyanka SinghbDepartment of Chemistry, National Institute of Technology, Raipur-492010 (CG), IndiaSearch for other works by this author on:Dharm Pal;Dharm PalcDepartment of Chemical Engineering, National Institute of Technology, Raipur-492010 (CG), IndiaSearch for other works by this author on:Awanish KumarAwanish KumaraDepartment of Biotechnology, National Institute of Technology, Raipur-492010 (CG), India [email protected]; [email protected]Search for other works by this author on:
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Chapter 7: Phytochemical-based Drugs for Salmonella Biofilm Disruptionp123-143ByNeha Sahu;Neha SahuaDepartment of Botany, University of Lucknow, Lucknow, U.P., India [email protected]Search for other works by this author on:Prabhat UpadhyayPrabhat UpadhyaybWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA [email protected]; [email protected]Search for other works by this author on:
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Chapter 8: Synthetic Compounds in Disruption of Salmonella Biofilmp144-159ByNiyati Kalaria;Niyati KalariaaBiotechnology and Bioinformatics Area, NIIT University, Neemrana, Rajasthan, IndiaSearch for other works by this author on:Aditya Upadhyay;Aditya UpadhyaybDepartment of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh, IndiaSearch for other works by this author on:Ashwini KumarAshwini KumarcDepartment of Life Sciences, Sharda School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India [email protected]Search for other works by this author on:
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Chapter 9: Combinatorial Drug Therapy for Salmonella Biofilm Disruptionp160-188ByRupal Dhariwal;Rupal DhariwalaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Aditya Upadhyay;Aditya UpadhyaybDepartment of Biotechnology, National Institute of Technology, Raipur-492010 (CG), IndiaSearch for other works by this author on:Khemraj Deshmukh;Khemraj DeshmukhcDepartment of Biomedical Engg, Mody University of Science and Technology, Lakshmangarh, Sikar, Rajasthan, India [email protected]Search for other works by this author on:Nil Patil;Nil PatilaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Bindiya Upadhyay;Bindiya UpadhyayaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Komal Janiyani;Komal JaniyaniaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:Harjeet Singh;Harjeet SinghdNarnarayan Shastri Institute of Technology-Institute of Forensic Science and Cyber Security (NSIT-IFSCS), Jetalpur, Ahmedabad, Gujarat, 382427, IndiaSearch for other works by this author on:Mukul JainMukul JainaResearch and Development Cell and Department of Life Sciences, PIAS, Parul University, Vadodara, Gujarat, IndiaSearch for other works by this author on:
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Chapter 10: Drug Repurposing as an Effective Solution to Control Salmonella Biofilm Infectionp189-202ByAditya Upadhyay;Aditya UpadhyayaDepartment of Biotechnology, National Institute of Technology, Raipur-492010 (CG), IndiaSearch for other works by this author on:Divya Sharma;Divya SharmabCentre for Study in Science Policy, School of Social Sciences, Jawaharlal Nehru University, New Delhi, IndiaSearch for other works by this author on:Awanish KumarAwanish KumaraDepartment of Biotechnology, National Institute of Technology, Raipur-492010 (CG), India [email protected]; [email protected]Search for other works by this author on:
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Chapter 11: Nanodrug Therapy for Salmonella Biofilm Disruptionp203-217ByShagun Rangra;Shagun RangraaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaSearch for other works by this author on:Arvee Prajapati;Arvee PrajapatiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaSearch for other works by this author on:Dhwani Rana;Dhwani RanaaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaSearch for other works by this author on:Nimeet Desai;Nimeet DesaiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaSearch for other works by this author on:Aditya Upadhyay;Aditya UpadhyaybDepartment of Biotechnology, National Institute of Technology, Raipur, CG 492010, IndiaSearch for other works by this author on:Vasanth Raj Palanimuthu;Vasanth Raj PalanimuthucChina Medical University-Queen’s University Belfast Joint College (CQC), China Medical University, Shenyang, ChinadSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UKSearch for other works by this author on:Derajram Benival;Derajram BenivalaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaSearch for other works by this author on:Lalitkumar VoraLalitkumar VoradSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK [email protected]Search for other works by this author on:
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Chapter 12: Future Discovery Path to Combat Salmonella Biofilm Infectionp218-274ByAranyak GoswamiAranyak GoswamiUniversity of Arkansas’ Dale Bumpers College of Agricultural, Food, and Life Sciences, USA [email protected]Search for other works by this author on:
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