Chapter 4: Antibiotic Therapy for Salmonella Biofilm Disruption

An increasing number of diseases caused by bacterially contaminated substances, particularly food, has been observed in recent times. It is notable that symptoms of fever, diarrhea, and gastroenteritis are prevalent where the presence of Salmonella is likely. In the planktonic stage, Salmonella does not cause significant detrimental effects; however, after irreversible attachment, bacterial cells form biofilms that are a major reason for higher pathogenicity. These bacterial biofilms allow the bacteria to survive on biotic and abiotic surfaces and in adverse conditions. This article provides information about the formation of Salmonella biofilms under various surface conditions. The mechanistic approach to disrupting biofilms by targeting several factors is discussed. However, recent case studies have highlighted the use of various antibiotics to combat different Salmonella species. Identifying effective methods to disrupt Salmonella biofilms could significantly reduce the number of cases of salmonellosis.