Chapter 6: Secondary Metabolites and Peptide Drug Therapy for Salmonella Biofilm Disruption

Secondary metabolites and peptide drug therapy are showing promise in disrupting Salmonella biofilms, which are concerning due to their role in chronic infections and antibiotic resistance. Approaches like combinatorial enzyme therapy and monoclonal antibodies targeting amyloid fibers have proven effective in disrupting bacterial biofilms. Peptides derived from insects have demonstrated antibiofilm potency against Staphylococcus aureus, indicating their potential in combating biofilm-producing bacteria. Computational methods have been used to predict the anti-biofilm effects of peptides, emphasizing the need for new therapeutic agents to combat biofilm-related infections. Overall, secondary metabolites and peptide drug therapy offer a novel and promising approach for disrupting Salmonella biofilms and addressing antibiotic resistance.