Chapter 8: Synthetic Compounds in Disruption of Salmonella Biofilm

Salmonella biofilms are known to present a substantial public health concern owing to their remarkable ability to persist and exhibit resistance towards traditional antibiotics. The utilization of synthetic molecules emerges as a promising and innovative strategy in the battle against these biofilms. These chemical compounds have a broad range of functions, including adhesion inhibitors, dispersion agents, matrix-degrading enzymes, and quorum sensing disruptors. Each of these capabilities is carefully engineered to target different aspects of biofilm formation and architecture. Through the disruption of bacterial interactions within the biofilm and the destabilization of its intricate structure, synthetic molecules effectively heighten bacterial vulnerability to antibiotics and the host immune system. It is crucial to carry out further research to refine these synthetic compounds and enable their translation into practical applications intended to improve the prevention of infections and eventually promote better patient outcomes.