Chapter 12: Future Discovery Path to Combat Salmonella Biofilm Infection Check Access

Salmonella, a significant foodborne pathogen, forms biofilms that enhance its resilience against environmental stressors and antimicrobial treatments, complicating infection control in food processing and the gastrointestinal tract of hosts. This chapter elucidates the biofilm formation process, highlighting its role in chronic infections and antimicrobial resistance. Comprehensive control measures include enzymatic degradation of biofilm matrix components using proteases, polysaccharide-degrading enzymes, DNases, and lipases. Biofilm-specific phage therapy targets and disrupts Salmonella within biofilms. Immunomodulatory agents, such as beta-glucans, enhance host immune responses. Probiotics, including Lactobacillus and Bifidobacterium species, and nutritional support with key nutrients like vitamin C and zinc fortify gut barrier function and modulate immune responses. Advanced approaches involve developing biofilm-resistant surfaces and quorum-sensing inhibitors to prevent biofilm formation. Additionally, therapeutic antibodies targeting Salmonella’s virulence factors and structural components are explored. By integrating these strategies, the chapter provides a holistic view of combating Salmonella biofilm infections, emphasizing the need for innovative and multifaceted approaches to enhance food safety and public health.