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Coordination Chemistry Perspectives
Iron in Biology: Molecular Structures, Cellular Processes and Living SystemsCheck Access
Edited by
Yoshitsugu Shiro;
Yoshitsugu Shiro
University of Hyogo, Japan
Search for other works by this author on:
Hitomi Sawai;
Hitomi Sawai
Osaka Metropolitan University, Japan
Search for other works by this author on:
Takehiko Tosha
Takehiko Tosha
University of Hyogo, Japan
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Volume
1
Hardback ISBN:
978-1-83767-440-4
PDF ISBN:
978-1-83767-797-9
EPUB ISBN:
978-1-83767-798-6
Special Collection:
2025 eBook Collection
No. of Pages:
372
Publication date:
13 Jun 2025
About this book
Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields are independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels.
This book focuses on iron (Fe) in cells, since it is the most abundant metal in living system and is involved in a variety of physiological events such as enzymatic reactions as catalysts and signal transduction. Both excess and shortage of iron cause serious diseases such as anaemia, cancer and neuronal degeneration. The cellular systems consisting of many specific proteins strictly control the iron contents through the iron dynamics in cells including absorption, sensing, storage, transport and usage.
Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life, by providing fundamental ideas on genetics, drugs and environmental health.
Iron in Biology: Molecular Structures, Cellular Processes and Living Systems, Royal Society of Chemistry, 2025.
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Digital access
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Print format
Iron in Biology
$280.00
Table of contents
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Section I: Diseases Relating to Cellular Iron Dynamics
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Chapter 1: Introduction to Iron Dynamics in Human Cells: Fundamental Mechanisms and Recent Developmentsp1-19ByIzumi Yanatori;Izumi YanatoriaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan[email protected]Search for other works by this author on:Hitomi SawaiHitomi SawaibDepartment of Chemistry, Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka City, Osaka 558-8585, JapancInstitute for Molecular Science, National Institute of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, JapanSearch for other works by this author on:
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Chapter 2: Dysregulated Iron Dynamics in Cancerp20-32ByShinya Toyokuni;Shinya ToyokuniaDepartment of Pathology and Biological Response, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, JapanbCenter for Low-temperature Plasma Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan[email protected]Search for other works by this author on:Yingyi KongYingyi KongaDepartment of Pathology and Biological Response, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, JapanSearch for other works by this author on:
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Chapter 3: Ferroptosis: Iron-dependent Non-apoptotic Cell Deathp33-47ByHiroaki FujitaHiroaki FujitaDepartment of Molecular and Cellular Physiology, Kyoto University School of Medicine, Japan[email protected]Search for other works by this author on:
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Chapter 4: Non-alcoholic Steatohepatitis: Pathophysiologic Role of Iron in Liver Fibrosisp48-57ByTakayoshi Suganami;Takayoshi SuganamiaDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, JapanbDepartment of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, JapancInstitute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya, JapandCenter for One Medicine Innovative Translational Research (COMIT), Nagoya University, Nagoya, JapaneQuantum-Based Frontier Research Hub for Industry Development, Nagoya University, Nagoya, JapanfInnovative Research Center for Preventive Medical Engineering, Nagoya University, Japan[email protected]Search for other works by this author on:Miyako TanakaMiyako TanakaaDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, JapanbDepartment of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, JapancInstitute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya, JapanSearch for other works by this author on:
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Chapter 5: Iron Dynamics in Pathogens and their Inhibition for Anti-pathogenic Drug Designp58-71ByM. Nakakido;M. NakakidoaThe University of Tokyo, Department of Bioengineering, School of Engineering, Hongo, Bunkyo-ku, Tokyo 113-8656, JapanSearch for other works by this author on:I. Nakagawa;I. NakagawabKyoto University, Department of Microbiology, Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, JapancKyoto University Center for Health Security, Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan[email protected]Search for other works by this author on:K. TsumotoK. TsumotoaThe University of Tokyo, Department of Bioengineering, School of Engineering, Hongo, Bunkyo-ku, Tokyo 113-8656, JapandMedical Proteomics Laboratory, The University of Tokyo, The Institute of Medical Science, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan[email protected]Search for other works by this author on:
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Section II: Proteins in Iron Dynamics
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Chapter 6: Iron Absorption in Human Duodenum by Dcytb and DMT1p73-88ByHitomi Sawai;Hitomi SawaiaDepartment of Chemistry, Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka City, Osaka 558-8585, JapanbInstitute for Molecular Science, National Institute of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan[email protected]Search for other works by this author on:Hiroshi Sugimoto;Hiroshi SugimotocRIKEN SPring-8 Centre, 1-1-1 Koto, Sayo-cho, Sayo-gun, Hyogo 679-5148, JapanSearch for other works by this author on:Yoshitsugu ShiroYoshitsugu ShirodGraduate School of Science, University of Hyogo, 3-2-1 Koto, Kamigori-cho, Ako-gun, Hyogo 678-1297, JapanSearch for other works by this author on:
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Chapter 7: Regulatory Systems of Iron Homeostasis in Human Cells with a Focus on IRPsp89-104ByKoichiro IshimoriKoichiro IshimoriDepartment of Chemistry, Faculty of Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo 060-0810, Japan[email protected]Search for other works by this author on:
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Chapter 8: Molecular Mechanisms of ABC Transporters Involved in Bacterial Heme Uptake and Effluxp105-120ByHiroshi Sugimoto;Hiroshi SugimotoaRIKEN SPring-8 Center, Japan[email protected]Search for other works by this author on:Tamao Hisano;Tamao HisanobRIKEN Center for Biosystems Dynamics Research, JapanSearch for other works by this author on:Yoshitsugu ShiroYoshitsugu ShirocGraduate School of Science, University of Hyogo, JapanSearch for other works by this author on:
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Chapter 9: Proteins Associated with Haem Catabolism for Iron Utilisation and Other Functions in Mammals and Photosynthetic Organismsp121-137ByM. Sugishima;M. SugishimaaKurume University, School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan[email protected]Search for other works by this author on:K. Wada;K. WadabUniversity of Miyazaki, Faculty of Medicine, 5200 Kiyotake Kihara, Miyazaki, 889-1692, JapanSearch for other works by this author on:J. TairaJ. TairacKyushu Institute of Technology, Graduate School of Computer Science and Systems Engineering, 680-4 Kawazu, Iizuka, 820-8502, JapanSearch for other works by this author on:
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Chapter 10: Allosteric Regulation of Heme-containing Respiratory Enzymes for Therapeutic Implications: Cytochrome c Oxidases and Nitric Oxide Reductasesp138-157ByYuya Nishida;Yuya NishidaDepartment of Molecular Pharmacology, National Cerebral and Cardiovascular Center, 6-1, Kishibe-Shimmachi, Suita, Osaka, JapanSearch for other works by this author on:Yasunori ShintaniYasunori ShintaniDepartment of Molecular Pharmacology, National Cerebral and Cardiovascular Center, 6-1, Kishibe-Shimmachi, Suita, Osaka, Japan[email protected]Search for other works by this author on:
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Chapter 11: Proteins Related to Iron Deficiency Responses and Iron Sensing in Plant Cellsp158-176ByTakanori KobayashiTakanori KobayashiResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan[email protected]Search for other works by this author on:
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Chapter 12: Iron-phytosiderophore and the Mechanism of its Uptake from Soilp177-194ByAtsushi Yamagata;Atsushi YamagataaLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, JapanSearch for other works by this author on:Kosuke Namba;Kosuke NambabDepartment of Pharmaceutical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima-shi, Tokushima 770-8505, JapanSearch for other works by this author on:Yoshiko MurataYoshiko MuratacBioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Souraku-gun, Kyoto 619-0284, Japan[email protected]Search for other works by this author on:
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Section III: Research Techniques and Applications of Iron Dynamics
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Chapter 13: Iron Complexes as Bio-inspired Catalysts for Efficient and Selective Oxidation of Organic Compoundsp195-215ByH. Fujisaki;H. FujisakiDepartment of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, JapanSearch for other works by this author on:T. Ishizuka;T. IshizukaDepartment of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, JapanSearch for other works by this author on:T. KojimaT. KojimaDepartment of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, Japan[email protected]Search for other works by this author on:
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Chapter 14: Development of Novel Catalysts for the Oxygenase Reactions Using Artificial Iron-containing Enzymesp216-230ByShinya Ariyasu;Shinya AriyasuDepartment of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8602, Japan[email protected]Search for other works by this author on:Osami ShojiOsami ShojiDepartment of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8602, Japan[email protected]Search for other works by this author on:
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Chapter 15: Recent Advances in Synthetic Models of Nitrogenase Cofactorsp231-248ByK. Tanifuji;K. TanifujiInstitute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan[email protected]Search for other works by this author on:Y. OhkiY. OhkiInstitute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, JapanSearch for other works by this author on:
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Chapter 16: Construction of Heme and Non-heme Iron Sensor Compounds, Which are Very Useful for Live-cell Imagingp249-262ByT. HirayamaT. HirayamaLaboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4, Daigaku-nishi, Gifu, 501-1196, Japan[email protected]Search for other works by this author on:
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Chapter 17: Artificial Haemoglobin: Development of Cyclodextrin-haem Complexes for Application in Biological and Medical Fieldsp263-286ByHiroaki Kitagishi;Hiroaki KitagishiDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Japan[email protected]Search for other works by this author on:Qiyue Mao;Qiyue MaoDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, JapanSearch for other works by this author on:Atsuki Nakagami;Atsuki NakagamiDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, JapanSearch for other works by this author on:Masahito KoderaMasahito KoderaDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, JapanSearch for other works by this author on:
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Chapter 18: Techniques for Characterization of Short-lived Intermediates Appearing in the Catalytic Reaction of Iron-containing Proteinsp287-306ByTakehiko Tosha;Takehiko ToshaaGraduate School of Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 679-1297, Japan[email protected]Search for other works by this author on:Masaki Horitani;Masaki HoritanibFaculty of Agriculture, Department of Applied Biochemistry and Food Science, Saga University, 1 Honjo-machi, Saga 840-8502, JapancThe United Graduate School of Agricultural Science, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, JapanSearch for other works by this author on:Yoshitsugu ShiroYoshitsugu ShiroaGraduate School of Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 679-1297, JapanSearch for other works by this author on:
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Chapter 19: Computational Chemistry Studies on Iron-containing Proteins Toward Understanding Underlying Mechanismsp307-323ByRikuri Morita;Rikuri MoritaCenter for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, JapanSearch for other works by this author on:Yuta Hori;Yuta HoriCenter for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, JapanSearch for other works by this author on:Yasuteru ShigetaYasuteru ShigetaCenter for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan[email protected]Search for other works by this author on:
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Chapter 20: Statistical Insight into Heme Structures and Their Diverse Utility in Proteinsp324-338ByY. Kanematsu;Y. KanematsuaGraduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1, Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8527, Japan[email protected]Search for other works by this author on:H. X. Kondo;H. X. KondobKitami Institute of Technology, Faculty of Engineering, 165 Koen-cho, Kitami Hokkaido 090-8507, JapanSearch for other works by this author on:Y. TakanoY. TakanocGraduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi, Asaminami-ku, Hiroshima 731-3194, JapanSearch for other works by this author on:
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