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Drug Development and Pharmaceutical Science
Targeted Radiopharmaceuticals and Imaging: Development Challenges and OpportunitiesCheck Access
Edited by
Ved Srivastava;
Ved Srivastava
Global Peptide Science Institute (GPSi), USA
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Rakhee Vatsa
Rakhee Vatsa
Tata Memorial Centre, India
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Volume
5
Hardback ISBN:
978-1-83767-327-8
EPUB ISBN:
978-1-83767-714-6
PDF ISBN:
978-1-83767-713-9
Special Collection:
2025 eBook Collection
No. of Pages:
502
Publication date:
04 Jun 2025
About this book
Targeted Radiopharmaceutical Therapy (RPT) is emerging as an innovative approach for treating a wide range of cancers.
Almost all radionuclides used in RPT emit photons that can be imaged, enabling non-invasive visualization of the therapeutic agent's biodistribution. The remarkable potential of radiopharmaceutical therapy is now being recognized with recent FDA approval of several RPT drugs and a significant number of drug candidates in clinical development.
This book offers a comprehensive perspective on the different technologies and addresses the critical challenges in developing and commercializing radiopharmaceuticals. It covers various topics, from clinical applications to specific radiopharmaceutical biodistribution, dosimetry, and novel targets in oncology. The chapters provide a cohesive picture of the advances in SPECT/CT and PET/CT imaging, clinical trends in targeted therapies utilizing radioisotopes for cancer imaging, and clinical applications of radiotracers within oncology areas. It also delves into the manufacturing technologies and regulatory and supply logistics required to support the development of the next wave of targeted alpha therapies.
This resource is ideal for postgraduates and researchers in drug discovery and development in radionuclide therapy and imaging in cancer, as well as medical professionals engaged in nuclear medicine and radiology.
Targeted Radiopharmaceuticals and Imaging: Development Challenges and Opportunities, Royal Society of Chemistry, 2025.
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Digital access
$280.00
Print format
Targeted Radiopharmaceuticals and Imaging
$280.00
Table of contents
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Chapter 1: Targeted Radiopharmaceuticals: Clinical Development and Commercial Landscapep1-20ByEsha Agarwal;Esha AgarwalaUniversity of North Carolina, Chapel Hill, NC 27599, USASearch for other works by this author on:Ved SrivastavaVed SrivastavabPerpetual Medicines, Research Triangle Park, NC 27519, USA [email protected]Search for other works by this author on:
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Chapter 2: Advances in Targeted Radiopharmaceuticals: Challenges and Opportunitiesp21-55BySomit Pandey;Somit PandeyaPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:Aarti Aggarwal;Aarti AggarwalaPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:Rakhee VatsaRakhee VatsabTata Memorial Centre, Advanced Centre for Treatment, Research, and Education in Cancer (ACTREC), Department of Nuclear Medicine, Kharghar, Navi Mumbai, 410210, India [email protected]Search for other works by this author on:
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Chapter 3: Alpha-particle Emitting Radiopharmaceuticals in Targeted Therapy and Diagnostics: Challenges and Opportunitiesp56-110ByHelena Koniar;Helena KoniaraTRIUMF, Life Sciences Division, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3, CanadabUniversity of British Columbia, Department of Physics and Astronomy, 6224 Agricultural Road, Vancouver, BC, V6T 1Z1, CanadaSearch for other works by this author on:Paul SchafferPaul SchafferaTRIUMF, Life Sciences Division, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3, CanadacSimon Fraser University, Department of Chemistry, 8888 University Drive, V5A 1S6 Burnaby, BC, V5A 1S6, CanadadUniversity of British Columbia, Department of Radiology, 2775 Laurel Street, 11th Floor, Vancouver, BC, V5Z 1M9, Canada [email protected]Search for other works by this author on:
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Chapter 4: Chelator Design and Radiolabeling Chemistry of Radiometalsp111-158ByViktoria E. Krol;Viktoria E. KrolaMayo Clinic, Department of Radiology, 200 1st Street, Rochester MN, 55905, USASearch for other works by this author on:Mukesh K. PandeyMukesh K. PandeyaMayo Clinic, Department of Radiology, 200 1st Street, Rochester MN, 55905, USAbMayo Clinic Comprehensive Cancer Center, 200 1st Street, Rochester MN, 55905, USAcMayo Clinic, Department of Pharmacology, 200 1st Street, Rochester MN, 55905, USA [email protected]Search for other works by this author on:
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Chapter 5: Dosimetry Methods for Radiopharmaceuticalsp159-201ByNivedita Rana;Nivedita RanaPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, India [email protected]Search for other works by this author on:Sejal Chopra;Sejal ChopraPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:Komalpreet KaurKomalpreet KaurPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:
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Chapter 6: Glypican-3 (GPC3) Targeted Radiopharmaceuticals for Treatment of Liver Cancerp202-216ByRongjun He;Rongjun HeaNeurocrine Biosciences, 12780 El Camino Real, San Diego, CA, 92130, USA [email protected]Search for other works by this author on:Adam Mezo;Adam MezoaNeurocrine Biosciences, 12780 El Camino Real, San Diego, CA, 92130, USA [email protected]Search for other works by this author on:Greg ChenGreg ChenbUS Rad Bio LLC, 10540 Stony Ridge Ct, San Diego, CA, 92131, USA [email protected]Search for other works by this author on:
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Chapter 7: Identifying New Molecular Modalities for Radionuclide Therapy Using Macrocyclic Peptide Mimeticsp217-237ByDeborah Charych;Deborah CharychUtter Therapeutics, San Francisco, CA 94107, USA [email protected]Search for other works by this author on:Thomas HardingThomas HardingUtter Therapeutics, San Francisco, CA 94107, USASearch for other works by this author on:
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Chapter 8: Peptides and Small Radiopharmaceuticals for Molecular Targetingp238-256ByJaya ShuklaJaya ShuklaPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh (160012), India [email protected]Search for other works by this author on:
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Chapter 9: Antibody Based Radiopharmaceuticals in Clinical Developmentp257-277BySneha Mithun;Sneha MithunaDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, IndiabHomi Bhabha National Institute (HBNI), Deemed University, Mumbai, IndiaSearch for other works by this author on:Kinnari Chitnis;Kinnari ChitnisaDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, IndiaSearch for other works by this author on:Bhakti Shetye;Bhakti ShetyeaDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, IndiabHomi Bhabha National Institute (HBNI), Deemed University, Mumbai, IndiaSearch for other works by this author on:Mythili Kameswaran;Mythili KameswaranaDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, IndiaSearch for other works by this author on:Ashish Kumar Jha;Ashish Kumar JhaaDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, IndiabHomi Bhabha National Institute (HBNI), Deemed University, Mumbai, IndiaSearch for other works by this author on:V. RangarajanV. RangarajanaDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, IndiabHomi Bhabha National Institute (HBNI), Deemed University, Mumbai, India [email protected]Search for other works by this author on:
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Chapter 10: Prostate-specific Membrane Antigen Targeted Prostate Imaging and Therapyp278-293ByGurvinder Kaur;Gurvinder KaurPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:Piyush Aggarwal;Piyush AggarwalPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:Jaya Shukla;Jaya ShuklaPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:Harmandeep Singh;Harmandeep SinghPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, India [email protected]Search for other works by this author on:Bhagwant Rai MittalBhagwant Rai MittalPostgraduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh, 160012, IndiaSearch for other works by this author on:
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Chapter 11: Radiotracers for Imaging of Breast Cancer and Targeted Radionuclide Therapyp294-308BySayak Choudhury;Sayak ChoudhuryAdvanced Centre for Treatment, Research, and Education in Cancer, Department of Nuclear Medicine, Kharghar, Navi Mumbai, 410210, India [email protected]Search for other works by this author on:Suchismita GhoshSuchismita GhoshAdvanced Centre for Treatment, Research, and Education in Cancer, Department of Nuclear Medicine, Kharghar, Navi Mumbai, 410210, IndiaSearch for other works by this author on:
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Chapter 12: Neuroendocrine Tumors: Radiopharmaceuticals for Imaging and Therapyp309-324ByPunit Sharma;Punit SharmaaDepartment of Nuclear Medicine, Apollo Multispeciality Hospital, Canal Circular Road, Kolkata, 700054, India [email protected]Search for other works by this author on:Shashank Shekhar SinghShashank Shekhar SinghbDepartment of Nuclear Medicine, Globe Healthcare, Nirala Nagar, Lucknow, 226020, IndiaSearch for other works by this author on:
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Chapter 13: Radiopharmaceuticals for Imaging and Therapy in Neurologyp325-341ByShelvin Kumar Vadi;Shelvin Kumar VadiaAmerican Oncology Institute @ Baby Memorial Hospital, Calicut, India [email protected]Search for other works by this author on:Junise MoideenJunise MoideenbTownsville University Hospital, Queensland, Australia [email protected]Search for other works by this author on:
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Chapter 14: Thyroid Imaging and Radionuclide Therapyp342-360ByPiyush Aggarwal;Piyush AggarwalPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh (160012), IndiaSearch for other works by this author on:Gurvinder Kaur;Gurvinder KaurPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh (160012), IndiaSearch for other works by this author on:Ashwani Sood;Ashwani SoodPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh (160012), India [email protected]Search for other works by this author on:Bhagwant Rai MittalBhagwant Rai MittalPost Graduate Institute of Medical Education and Research, Department of Nuclear Medicine, Chandigarh (160012), IndiaSearch for other works by this author on:
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Chapter 15: Radiopharmaceuticals for Skeletal Imaging and Therapyp361-381ByNavneet Kumar;Navneet KumarAll India Institute of Medical Science, Department of Nuclear Medicine, Bhubaneswar, IndiaSearch for other works by this author on:Tejasvini Singhal;Tejasvini SinghalAll India Institute of Medical Science, Department of Nuclear Medicine, Bhubaneswar, IndiaSearch for other works by this author on:Kanhaiyalal AgrawalKanhaiyalal AgrawalAll India Institute of Medical Science, Department of Nuclear Medicine, Bhubaneswar, India [email protected]Search for other works by this author on:
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Chapter 16: Radiopharmaceuticals in Dermatologic Imaging and Therapyp382-397ByKiruthika Subburaj;Kiruthika SubburajaDepartment of Dermatology, Dharan Hospital and Cancer Speciality Centre, Salem, Tamil Nadu, IndiaSearch for other works by this author on:Venkata Subramanian Krishnaraju;Venkata Subramanian KrishnarajubDepartment of Nuclear Medicine, Dharan Hospital and Cancer Speciality Centre, Salem, Tamil Nadu, India [email protected]Search for other works by this author on:Anjugam AlagappanAnjugam AlagappancDepartment of Dermatology, Arunai Medical College and Hospital, Tiruvannamalai, Tamil Nadu, IndiaSearch for other works by this author on:
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Chapter 17: Targeted Radiopharmaceuticals for Infection Imagingp398-410ByM. Ganesh KumarM. Ganesh KumarDepartment of Nuclear Medicine, Kiran Multi Superspeciality Hospital, Surat, India [email protected]Search for other works by this author on:
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Chapter 18: Manufacturing Challenges and Radiopharmaceutical Application of 18F-labeled Heterocycles for PET Imagingp411-434ByVaezeh Fathi Vavsari;Vaezeh Fathi VavsariPeptide Chemistry Research Institute, K. N. Toosi University of Technology, Tehran 1996715433, Iran [email protected]Search for other works by this author on:Farhad Golmohammadi;Farhad GolmohammadiPeptide Chemistry Research Institute, K. N. Toosi University of Technology, Tehran 1996715433, IranSearch for other works by this author on:Saeed BalalaieSaeed BalalaiePeptide Chemistry Research Institute, K. N. Toosi University of Technology, Tehran 1996715433, Iran [email protected]Search for other works by this author on:
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Chapter 19: Quality Considerations in Radiopharmaceuticalsp435-452ByAnupriya Chhabra;Anupriya ChhabraaJohns Hopkins University, School of Medicine, Department of Radiology, 1550 Orleans St., Baltimore, 21287, USA [email protected]Search for other works by this author on:Karan Singh TanwarKaran Singh TanwarbTata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Department of Nuclear Medicine, Kharghar, Mumbai, 410210, IndiaSearch for other works by this author on:
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