CHAPTER 3: Synthesis and Characterization of Glycopolypeptides Check Access
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Published:23 Mar 2015
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Series: Polymer Chemistry Series
K. Krannig and H. Schlaad, in Glycopolymer Code: Synthesis of Glycopolymers and Their Applications, ed. C. R. Becer and L. Hartmann, The Royal Society of Chemistry, 2015, pp. 77-95.
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Polypeptides carrying carbohydrate side chains, referred to as glycopolypeptides, are designed for use in advanced biomedical and life science applications. However, the synthesis of well-defined glycopolypeptide materials has been a great challenge until recently. Here, the state-of-the-art in the production of glycopolypeptides by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs) is described, including the synthesis of NCA monomers, controlled polymerization protocols and post-polymerization (click) glycosylation reactions.
