Chapter 4: Greener Solvent Usage for Discovery Chemistry Analysis and Purification

The concept of green chemistry has been implemented in chemical manufacturing and process chemistry over the past 15 years. Only recently has the concept been introduced to smaller volume activities such as medicinal and analytical chemistry. This chapter discusses green chemistry approaches suitable for discovery chemistry analysis and purification. Topics covered include use of supercritical fluid chromatography (SFC) for analysis and purification to reduce solvent usage, optimizing analytical LC methods to minimize solvent usage, optimization of reverse phase purifications, use of greener solvents for flash purification, and an evaluation of flash SFC for discovery chemistry purifications. Approaches that have been successful in numerous pharmaceutical medicinal chemistry laboratories will be presented.