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Drug Discovery
Green Chemistry Strategies for Drug DiscoveryCheck Access
Edited by
Julie B. Manley
Julie B. Manley
Guiding Green LLC, USA
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Hardback ISBN:
978-1-84973-961-0
PDF ISBN:
978-1-78262-265-9
EPUB ISBN:
978-1-78262-553-7
Special Collection:
2015 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery Series
No. of Pages:
322
Published online:
11 Jun 2015
Published in print:
26 Jun 2015
Book Chapter
Chapter 3: Toward a Green Laboratory: One Reaction at a Time Check Access
By
Leanna E. Shuster
;
Leanna E. Shuster
GlaxoSmithKline
1250 South Collegeville Road
Collegeville, PA
19426
USA
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Anikó M. Redman
Anikó M. Redman
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-
Published:11 Jun 2015
-
Special Collection: 2015 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery Series
Page range:
39 - 65
Citation
L. E. Shuster and A. M. Redman, in Green Chemistry Strategies for Drug Discovery, ed. E. A. Peterson and J. B. Manley, The Royal Society of Chemistry, 2015, ch. 3, pp. 39-65.
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The choice of small scale reaction conditions in drug discovery can have significant impact, both in cumulative material use throughout the industry and by influencing methods of further scale-up processes. Design of synthetic routes and choice of solvents and reagents are discussed along with greener techniques for reaction setup and workup. Specific examples are highlighted to provide chemists with a wider range of synthetic options beyond the scope of traditional medicinal chemistry practices.
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