Chapter 3: Toward a Green Laboratory: One Reaction at a Time
Published:11 Jun 2015
Special Collection: 2015 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery
The choice of small scale reaction conditions in drug discovery can have significant impact, both in cumulative material use throughout the industry and by influencing methods of further scale-up processes. Design of synthetic routes and choice of solvents and reagents are discussed along with greener techniques for reaction setup and workup. Specific examples are highlighted to provide chemists with a wider range of synthetic options beyond the scope of traditional medicinal chemistry practices.