Carbohydrates in Drug Design and Discovery
In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery.
Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery.
Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.
Carbohydrates in Drug Design and Discovery, The Royal Society of Chemistry, 2015.
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Table of contents
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Chapter 1: Carbohydrate–Protein Interactions: A 3D View by NMRp1-20ByAna Ardá;Ana ArdáChemical and Physical Biology, CIB-CSICRamiro de Maeztu 928040MadridSpainSearch for other works by this author on:Angeles Canales;Angeles CanalesChemical and Physical Biology, CIB-CSICRamiro de Maeztu 928040MadridSpainSearch for other works by this author on:F. Javier Cañada;F. Javier CañadaChemical and Physical Biology, CIB-CSICRamiro de Maeztu 928040MadridSpainSearch for other works by this author on:Jesús Jiménez-BarberoJesús Jiménez-BarberoChemical and Physical Biology, CIB-CSICRamiro de Maeztu 928040MadridSpainIkerbasque, Basque Foundation for ScienceBilbaoSpainSearch for other works by this author on:
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Chapter 2: NMR as a Tool to Unveil the Molecular Basis of Glycan-mediated Host–Pathogen Interactionsp21-37ByRoberta Marchetti;Roberta MarchettiDipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant’AngeloVia Cintia 4I-80126NapoliItaly[email protected][email protected]Search for other works by this author on:Antonio Molinaro;Antonio MolinaroDipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant’AngeloVia Cintia 4I-80126NapoliItaly[email protected][email protected]Search for other works by this author on:Alba SilipoAlba SilipoDipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant’AngeloVia Cintia 4I-80126NapoliItaly[email protected][email protected]Search for other works by this author on:
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Chapter 3: Lipopolysaccharides as Microbe-associated Molecular Patterns: A Structural Perspectivep38-63ByFlaviana Di Lorenzo;Flaviana Di LorenzoDepartment of Chemical Sciences, University of Naples Federico IIVia Cinthia 480126NaplesItaly[email protected]Search for other works by this author on:Cristina De Castro;Cristina De CastroDepartment of Chemical Sciences, University of Naples Federico IIVia Cinthia 480126NaplesItaly[email protected]Search for other works by this author on:Rosa Lanzetta;Rosa LanzettaDepartment of Chemical Sciences, University of Naples Federico IIVia Cinthia 480126NaplesItaly[email protected]Search for other works by this author on:Michelangelo Parrilli;Michelangelo ParrilliDepartment of Chemical Sciences, University of Naples Federico IIVia Cinthia 480126NaplesItaly[email protected]Search for other works by this author on:Alba Silipo;Alba SilipoDepartment of Chemical Sciences, University of Naples Federico IIVia Cinthia 480126NaplesItaly[email protected]Search for other works by this author on:Antonio MolinaroAntonio MolinaroDepartment of Chemical Sciences, University of Naples Federico IIVia Cinthia 480126NaplesItaly[email protected]Search for other works by this author on:
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Chapter 4: Molecular Basis of Mycobacterium tuberculosis Recognition by the C-Type Lectin DC-SIGN: from the Modulation of Innate Immune Response to the Design of Innovative Anti-inflammatory Drugsp64-88ByEmilyne Blattes;Emilyne BlattesCNRS, Institut de Pharmacologie et de Biologie Structurale205 route de NarbonneF-31077ToulouseFrance[email protected]Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie StructuraleF-31077ToulouseFranceSearch for other works by this author on:Alain Vercellone;Alain VercelloneCNRS, Institut de Pharmacologie et de Biologie Structurale205 route de NarbonneF-31077ToulouseFrance[email protected]Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie StructuraleF-31077ToulouseFranceSearch for other works by this author on:Sandro Silva-Gomes;Sandro Silva-GomesCNRS, Institut de Pharmacologie et de Biologie Structurale205 route de NarbonneF-31077ToulouseFrance[email protected]Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie StructuraleF-31077ToulouseFranceSearch for other works by this author on:Jacques Prandi;Jacques PrandiCNRS, Institut de Pharmacologie et de Biologie Structurale205 route de NarbonneF-31077ToulouseFrance[email protected]Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie StructuraleF-31077ToulouseFranceSearch for other works by this author on:Jérôme NigouJérôme NigouCNRS, Institut de Pharmacologie et de Biologie Structurale205 route de NarbonneF-31077ToulouseFrance[email protected]Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie StructuraleF-31077ToulouseFranceSearch for other works by this author on:
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Chapter 5: Glyconanotechnology and Disease: Gold Nanoparticles Coated with Glycosides as Multivalent Systems for Potential Applications in Diagnostics and Therapyp89-131ByMarco Marradi;Marco MarradiLaboratory of GlycoNanotechnology, Biofunctional Nanomaterials Unit, CIC biomaGUNEPaseo Miramón 18220009San SebastiánSpainBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)Paseo Miramón 18220009San SebastiánSpain[email protected]Search for other works by this author on:Fabrizio Chiodo;Fabrizio ChiodoLaboratory of GlycoNanotechnology, Biofunctional Nanomaterials Unit, CIC biomaGUNEPaseo Miramón 18220009San SebastiánSpainSearch for other works by this author on:Isabel GarcíaIsabel GarcíaLaboratory of GlycoNanotechnology, Biofunctional Nanomaterials Unit, CIC biomaGUNEPaseo Miramón 18220009San SebastiánSpainBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)Paseo Miramón 18220009San SebastiánSpain[email protected]Search for other works by this author on:
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Chapter 6: Boosting Humoral Immune Responses to Tumor-associated Carbohydrate Antigens with Virus-like Particlesp132-150ByZhaojun Yin;Zhaojun YinDepartment of Chemistry, Chemistry Building, 578 S. Shaw Lane, Michigan State UniversityEast Lansing, MI48824USA[email protected]Search for other works by this author on:Xuefei HuangXuefei HuangDepartment of Chemistry, Chemistry Building, 578 S. Shaw Lane, Michigan State UniversityEast Lansing, MI48824USA[email protected]Search for other works by this author on:
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Chapter 7: Synthetic Glycosylated Ether Glycerolipids as Anticancer Agentsp151-179ByGilbert Arthur;Gilbert ArthurDepartment of Biochemistry and Medical Genetics, University of Manitoba754 Bannatyne AvenueWinnipeg, ManitobaCanadaR3E 0J9Search for other works by this author on:Frank Schweizer;Frank SchweizerDepartment of Chemistry and Medical Microbiology, University of Manitoba460 Parker BuildingWinnipeg, ManitobaCanadaR3T 2N2[email protected]Search for other works by this author on:Makanjuola OgunsinaMakanjuola OgunsinaDepartment of Chemistry and Medical Microbiology, University of Manitoba460 Parker BuildingWinnipeg, ManitobaCanadaR3T 2N2[email protected]Search for other works by this author on:
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Chapter 8: Carbohydrates and Glycomimetics in Alzheimer's Disease Therapeutics and Diagnosisp180-208ByCatarina Dias;Catarina DiasCentro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande1749-016LisbonPortugal[email protected]Search for other works by this author on:Amélia P. RauterAmélia P. RauterCentro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande1749-016LisbonPortugal[email protected]Search for other works by this author on:
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Chapter 9: Galactofuranose Biosynthesis: Discovery, Mechanisms and Therapeutic Relevancep209-241ByGuillaume Eppe;Guillaume EppeUniversity of Namur, Département de Chimie, Laboratoire de Chimie Bio-Organiquerue de Bruxelles 61B-5000NamurBelgium[email protected]Search for other works by this author on:Sandy El Bkassiny;Sandy El BkassinyUniversity of Namur, Département de Chimie, Laboratoire de Chimie Bio-Organiquerue de Bruxelles 61B-5000NamurBelgium[email protected]Search for other works by this author on:Stéphane P. VincentStéphane P. VincentUniversity of Namur, Département de Chimie, Laboratoire de Chimie Bio-Organiquerue de Bruxelles 61B-5000NamurBelgium[email protected]Search for other works by this author on:
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Chapter 10: Carbohydrate-containing Matrix Metalloproteinase Inhibitors (MMPIs): A Second Childhood for Sulfonamidic Inhibitors?p242-254ByCristina Nativi;Cristina NativiDipartimento di Chimica, Università di Firenze, via della Lastruccia 13Sesto F.no (Fi)50019ItalySearch for other works by this author on:Barbara Richichi;Barbara RichichiDipartimento di Chimica, Università di Firenze, via della Lastruccia 13Sesto F.no (Fi)50019ItalySearch for other works by this author on:Stefano RoelensStefano RoelensCNR, Istituto di Metodologie Chimiche (IMC), Dipartimento di Chimica, via della Lastruccia 13Sesto F.no (Fi)50019Italy[email protected]Search for other works by this author on:
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Chapter 11: Amphiphilic Aminoglycoside Antimicrobials in Antibacterial Discoveryp255-285ByFrank SchweizerFrank SchweizerSearch for other works by this author on:
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Chapter 12: From the Capsular Polysaccharide to a Conjugate Vaccine Containing Haemophilus influenzae Type b Synthetic Oligosaccharidep286-307ByVicente Vérez BencomoVicente Vérez BencomoSearch for other works by this author on:
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