Chapter 6: Boosting Humoral Immune Responses to Tumor-associated Carbohydrate Antigens with Virus-like Particles

The development of carbohydrate-based anticancer vaccines is an attractive approach towards the prevention and treatment of cancer. The weak immunogenicity of carbohydrate antigens and tolerance by the immune system are major obstacles towards the design of effective cancer vaccines. Recently, virus-like particles have been shown to be a promising platform to overcome the aforementioned difficulties. In this chapter, we provide an overview on the structural and immunological features of virus-like particles in eliciting anti-carbohydrate antibody responses. The immuno-potentiating activities of several virus-like particle systems are compared, and insights into critical factors of virus-like particles that help shape the anti-carbohydrate responses are discussed.