Chapter 9: Easy Ambient Sonic-Spray Ionization

The principles and major applications of one of the simpliest and easiest mass spectrometric techniques, that is, easy ambient sonic-spray ionization (EASI), able to effficiently desorb and ionize analytes at ambient conditions, is described. Several benefitial figures-of-merit for EASI are discussed and the EASI benefits of enhanced selectivity and S/N ratios are also emphazised. The lack of thermal, eletrical or discharge interferences and extreme easiness also points to EASI as an atractive protocol for simple, direct MS chemical analysis. The appications of this easy and simple heat and voltage-free ionization technique, including a disposable version, particularly suitable for instance to protable mass spectrometers, in a variety of fields including forensic, drug, clinical, fuel, food and environmental analysis is also illustrated.