CHAPTER 16: Paper Spray

Paper spray for direct mass spectrometry analysis is introduced in this chapter. The fundamental study of the mechanism and the characterization of the analytical performance are reviewed for paper spray mass spectrometry (PS-MS). An important aspect in development of paper spray is its capability for quantitation at high precision for analytes in complex samples, which is important for a wide range of applications in many different fields with mandatory criteria in quantitation. Its potential for point-of-care (POC) analysis is discussed with recent implementation with miniature MS analytical systems. Three other ambient ionization methods associated with paper spray, including leaf spray, tissue spray, and extraction spray ionization are also introduced in this chapter.