CHAPTER 18: Enabling Automated Sample Analysis by Direct Analysis in Real Time (DART) Mass Spectrometry

Accurate chemical measurements are often generated by using complex sampling systems designed to deliver exact volumes of sample to the site of measurement. Sample preparation for analytical mass spectrometry can be labor intensive even when using robotic sample handling devices. Ambient ionization presents a different sampling challenge for analytical chemist since samples can be analyzed in their original form whether it be a solid or a liquid. The dream of “skip the prep go direct” would be fulfilled if it were possible to completely characterize a sample by simply holding it in the ionizing region and collecting the mass spectrum. This work describes our efforts to design and fabricate an easy-to-use, inexpensive sample presentation system for use with our direct analysis in real time (DART) desorption ionization source. The use of sample-specific experimental modules will be presented along with results from pharmaceutical tablet characterization for detection of trace pesticide residues in foodstuffs.