CHAPTER 8: Structural Studies of Small Bioactive Compounds Interacting with Membranes and Proteins
Published:24 Feb 2014
S. Matsuoka and M. Murata, in Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides, ed. F. Separovic and A. Naito, The Royal Society of Chemistry, 2014, pp. 133-161.
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This review describes the brief theory and some applications of solid-state NMR techniques that are frequently used for small compounds, including membrane lipids and drugs. We further focus on intermolecular interactions in dynamic systems that are not usually obtainable by X-ray crystallographic structures. In particular, recent studies on the structures and interactions of small bioactive compounds in membranes are reviewed in more detail because they often exert their action in a membrane-bound form. In addition, small compounds that interact with protein aggregates and polymeric proteins, such as amyloids and tubulin, are examined.