CHAPTER 8: Structural Studies of Small Bioactive Compounds Interacting with Membranes and Proteins

This review describes the brief theory and some applications of solid-state NMR techniques that are frequently used for small compounds, including membrane lipids and drugs. We further focus on intermolecular interactions in dynamic systems that are not usually obtainable by X-ray crystallographic structures. In particular, recent studies on the structures and interactions of small bioactive compounds in membranes are reviewed in more detail because they often exert their action in a membrane-bound form. In addition, small compounds that interact with protein aggregates and polymeric proteins, such as amyloids and tubulin, are examined.