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Drug Discovery
Fragment-Based Drug Discovery
Edited by
Chris Abell
Chris Abell
University of Cambridge, UK
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Hardback ISBN:
978-1-84973-908-5
PDF ISBN:
978-1-78262-093-8
EPUB ISBN:
978-1-78262-565-0
Special Collection:
2015 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery Series
No. of Pages:
314
Published online:
17 Jun 2015
Published in print:
03 Jul 2015
Book Chapter
CHAPTER 3: Applications of NMR in Fragment-Based Drug Design
By
Isabelle Krimm
Isabelle Krimm
Institut des Sciences Analytiques, UMR CNRS 5280, Université Lyon
5 rue de la Doua
69100 Villeurbanne
France
[email protected]
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Published:17 Jun 2015
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Special Collection: 2015 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery Series
Page range:
49 - 72
Citation
I. Krimm, in Fragment-Based Drug Discovery, ed. S. Howard and C. Abell, The Royal Society of Chemistry, 2015, pp. 49-72.
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The role of NMR in drug discovery has been significantly reinforced over recent years, particularly in the field of fragment-based drug design. NMR is one of the most robust methods for screening fragment libraries against therapeutic targets, generating few false positives. The application of ligand-observed and protein-observed experiments (STD, WaterLOGSY, transferred-NOESY and 2D-HSQC) is reviewed in this chapter, showing that NMR is also a powerful method for analysing the 3D structures of protein–fragment complexes.
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