CHAPTER 7: Disrupted-in-Schizophrenia-1 (DISC1) Interactome and Schizophrenia
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Published:28 Apr 2015
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Special Collection: 2015 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery
T. V. Lipina and J. C. Roder, in Drug Discovery for Schizophrenia, ed. T. Lipina and J. Roder, The Royal Society of Chemistry, 2015, pp. 141-172.
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Disrupted-in-schizophrenia-1 (DISC1) has captured much attention, because it predisposes individuals to such a psychiatric disorder as schizophrenia. Notably, a number of genes encoding proteins that interact with DISC1 are also considered to be relevant risk factors for this mental disorder. Accumulating studies reveal a role of DISC1 and its interacting proteins in early neurodevelopment and the regulation of synaptic functioning. We reason that the understanding of schizophrenia in the context of the DISC1 interactome will help to understand the neurobiological mechanisms of schizophrenia. Given that DISC1 is associated with a wide range of endophenotypes, systematic integration of the functional roles of each of the DISC1 interacting proteins would contribute to a better resolution of the neurobiological mechanisms of schizophrenia and ultimately lead to the development of preventive therapy.
