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Drug Discovery for Schizophrenia

RSC Drug Discovery Series


Professor David Thurston, King’s College, London, UK

Series Editors:

Professor David Rotella, Montclair State University, USA

Professor Ana Martinez, Centro de Investigaciones Biologicas-CSIC, Madrid, Spain

Dr David Fox, Vulpine Science and Learning, UK

Advisor to the Board:

Professor Robin Ganellin, University College London, UK

Titles in the Series:

1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups

2: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 1

3: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 2

4: Accounts in Drug Discovery

5: New Frontiers in Chemical Biology

6: Animal Models for Neurodegenerative Disease

7: Neurodegeneration

8: G Protein-Coupled Receptors

9: Pharmaceutical Process Development

10: Extracellular and Intracellular Signaling

11: New Synthetic Technologies in Medicinal Chemistry

12: New Horizons in Predictive Toxicology

13: Drug Design Strategies: Quantitative Approaches

14: Neglected Diseases and Drug Discovery

15: Biomedical Imaging

16: Pharmaceutical Salts and Cocrystals

17: Polyamine Drug Discovery

18: Proteinases as Drug Targets

19: Kinase Drug Discovery

20: Drug Design Strategies: Computational Techniques and Applications

21: Designing Multi-Target Drugs

22: Nanostructured Biomaterials for Overcoming Biological Barriers

23: Physico-Chemical and Computational Approaches to Drug Discovery

24: Biomarkers for Traumatic Brain Injury

25: Drug Discovery from Natural Products

26: Anti-Inflammatory Drug Discovery

27: New Therapeutic Strategies for Type 2 Diabetes: Small Molecules

28: Drug Discovery for Psychiatric Disorders

29: Organic Chemistry of Drug Degradation

30: Computational Approaches to Nuclear Receptors

31: Traditional Chinese Medicine

32: Successful Strategies for the Discovery of Antiviral Drugs

33: Comprehensive Biomarker Discovery and Validation for Clinical Application

34: Emerging Drugs and Targets for Parkinson’s Disease

35: Pain Therapeutics; Current and Future Treatment Paradigms

36: Biotherapeutics: Recent Developments using Chemical and Molecular Biology

37: Inhibitors of Molecular Chaperones as Therapeutic Agents

38: Orphan Drugs and Rare Diseases

39: Ion Channel Drug Discovery

40: Macrocycles in Drug Discovery

41: Human-based Systems for Translational Research

42: Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics

43: Carbohydrates in Drug Design and Discovery

44: Drug Discovery for Schizophrenia

How to obtain future titles on publication:

A standing order plan is available for this series. A standing order will bring delivery of each new volume immediately on publication.

For further information please contact:

Book Sales Department, Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK

Telephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247,

Visit our website at

Drug Discovery for Schizophrenia

Edited by

Tatiana V. Lipina

Institute of Physiology, Novosibirsk, Russia

John C. Roder

Lunenfeld–Tanenbaum Research Institute, Toronto, Canada



RSC Drug Discovery Series No. 44

Print ISBN: 978-1-78262-026-6

PDF eISBN: 978-1-78262-249-9

ISSN: 2041-3203

A catalogue record for this book is available from the British Library

© The Royal Society of Chemistry 2015

All rights reserved

Apart from fair dealing for the purposes of research for non-commercial purposes or for private study, criticism or review, as permitted under the Copyright, Designs and Patents Act 1988 and the Copyright and Related Rights Regulations 2003, this publication may not be reproduced, stored or transmitted, in any form or by any means, without the prior permission in writing of The Royal Society of Chemistry or the copyright owner, or in the case of reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page.

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Published by The Royal Society of Chemistry,

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Cambridge CB4 0WF, UK

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