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Drug Discovery
Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation
Edited by
Stefan Bräse
Stefan Bräse
Karlsruhe Institute of Technology, Germany
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Hardback ISBN:
978-1-78262-030-3
PDF ISBN:
978-1-78262-224-6
EPUB ISBN:
978-1-78262-779-1
Special Collection:
2015 ebook collection
Series:
Drug Discovery Series
No. of Pages:
468
Publication date:
20 Nov 2015
Book Chapter
Chapter 4: (Benz)imidazoles
By
Roland Pfau
Roland Pfau
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Published:20 Nov 2015
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Special Collection: 2015 ebook collectionSeries: Drug Discovery Series
Page range:
98 - 114
Citation
R. Pfau, in Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation, ed. S. Bräse, The Royal Society of Chemistry, 2015, ch. 4, pp. 98-114.
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Imidazoles and benzimidazoles are quite unique and universal scaffolds, which are core units in numerous drugs and drug candidates. Exhibiting unique properties, they can be viewed as amide-bond and indole bioisosters, but offering additional options for interactions. After a more general description of their intrinsic physicochemical and structural properties, the most important, as well as instructive examples of marketed drugs utilizing imidazoles and benzimidazoles as scaffolds will be presented and briefly discussed.
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