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Drug Discovery
Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation
Edited by
Stefan Bräse
Stefan Bräse
Karlsruhe Institute of Technology, Germany
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Hardback ISBN:
978-1-78262-030-3
PDF ISBN:
978-1-78262-224-6
EPUB ISBN:
978-1-78262-779-1
Special Collection:
2015 ebook collection
Series:
Drug Discovery Series
No. of Pages:
468
Publication date:
20 Nov 2015
Book Chapter
Chapter 5: Pyrazoles
By
Carsten S. Kramer
Carsten S. Kramer
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Published:20 Nov 2015
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Special Collection: 2015 ebook collectionSeries: Drug Discovery Series
Page range:
115 - 131
Citation
C. S. Kramer, in Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation, ed. S. Bräse, The Royal Society of Chemistry, 2015, ch. 5, pp. 115-131.
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There are not many examples of natural products that bear pyrazole moieties, but despite this observation, unnatural pyrazole derivatives are highly biologically active and can be found in numerous drugs. The first part of this chapter is a general description of the physicochemical properties of pyrazoles and different strategies for their synthesis are explained. The second part presents (former) marketed drugs utilizing pyrazoles as scaffolds.
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